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N6-Methyladenosine

N6-Methyladenosine

  • CAT Number: I002413
  • CAS Number: 1867-73-8
  • Molecular Formula: C11H15N5O4
  • Molecular Weight: 281.27
  • Purity: ≥95%
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<p style=/line-height:25px/>N6-Methyladenosine is an abundant nucleoside in cellular mRNA that undergoes demethylation under physiological conditions by fat mass and obesity-associated protein(FTO).<br>IC50 value:<br>Target:<br>N6-methyladenosine (m6A) is the most prevalent internal (non-cap) modification present in the messenger RNA of all higher eukaryotes. The recent discovery of two m(6)A demethylases in mammalian cells highlighted the importance of m(6)A in basic biological functions and disease. Here we show that m(6)A is selectively recognized by the human YTH domain family 2 (YTHDF2) /’reader/’ protein to regulate mRNA degradation.<br></p>

Catalog Number I002413
CAS Number 1867-73-8
Synonyms

(2R,3S,4R,5R)-2-(hydroxymethyl)-5-(6-(methylamino)-9H-purin-9-yl)tetrahydrofuran-3,4-diol

Molecular Formula

C11H15N5O4

Purity 95%
Target Adenylate cyclase
Solubility DMSO: ≥ 31 mg/mL
Storage 3 years -20C powder
Reference

<p style=/line-height:25px/>
<br>[1]. Wang X, et al. N6-methyladenosine-dependent regulation of messenger RNA stability. Nature. 2014 Jan 2;505(7481):117-20.
<br>[2]. Jia G, et al. N6-methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO. Nat Chem Biol. 2011 Oct 16;7(12):885-7.
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