N-Methyl-2-[[3-[(1E)-2-(2-pyridinyl)ethenyl]-1H-indazol-6-yl]sulfonyl]benzamide

• CAT Number: C000804
• CAS Number: 1348536-59-3
• Molecular Formula: C₂₂H₁₈N₄O₃S
• Molecular Weight: 418.47
• Purity: ≥95%
• Synonyms: Axitinib sulfone
• Solubility: DMSO (Slightly), Methanol (Slightly)
• Storage: -20°C, Inert atmosphere
• IUPAC Name: N-methyl-2-[[3-[(E)-2-pyridin-2-ylethenyl]-1H-indazol-6-yl]sulfonyl]benzamide
• InChI: InChI=1S/C22H18N4O3S/c1-23-22(27)18-7-2-3-8-21(18)30(28,29)16-10-11-17-19(25-26-20(17)14-16)12-9-15-6-4-5-13-24-15/h2-14H,1H3,(H,23,27)(H,25,26)/b12-9+
• InChIKey: UDHVZPNZJDOMGL-FMIVXFBMSA-N
• SMILES: CNC(=O)C1=CC=CC=C1S(=O)(=O)C2=CC3=C(C=C2)C(=NN3)C=CC4=CC=CC=N4

N-Methyl-2-[[3-[(1E)-2-(2-pyridinyl)ethenyl]-1H-indazol-6-yl]sulfonyl]benzamide (Cat No.:C000804) is a chemical compound characterized by a sulfonamide group linked to an indazole scaffold bearing a pyridinyl-ethenyl moiety. This intricate structure indicates potential significance in medicinal chemistry. The compound may act as a kinase inhibitor, potentially modulating cellular signaling pathways. Researchers likely explore its pharmacological effects on protein kinases and its potential therapeutic applications, particularly in oncology.

Reference

Wasser, K., et al.: Eur. Radiol., 13, 80 (2003), Park, J., et al.: Clin. Cancer Res., 8, 1172 (2002), Bergers, G., et al.: J. Clin. Invest., 111, 1287 (2003),