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N-Desmethyl Loperamide

N-Desmethyl Loperamide

  • CAT Number: R010492
  • CAS Number: 66164-07-6
  • Molecular Formula: C28H31ClN2O2
  • Molecular Weight: 463.018
  • Purity: ≥95%
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Loperamide (Item No. <span class=/itemid/>14875</span>) is an opiate which potently and selectively activates μ opioid receptors (K<sub>i</sub> = 0.16 nM) exclusively in the periphery. N-<wbr></wbr>Desmethyl-<wbr></wbr>loperamide (dLop) is a major metabolite of loperamide. Like loperamide, dLop is a substrate of the ATP-<wbr></wbr>dependent efflux transporter, P-<wbr></wbr>glycoprotein. As a result, both the parent compound and the metabolite display restricted passage through the blood-<wbr></wbr>brain barrier. dLop in biological samples can be analyzed by a variety of methods.

Catalog Number R010492
CAS Number 66164-07-6
Molecular Formula

C28H31ClN2O2

Purity 95%
Storage -20°C
IUPAC Name 4-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-N-methyl-2,2-diphenylbutanamide
InChI InChI=1S/C28H31ClN2O2/c1-30-26(32)28(23-8-4-2-5-9-23,24-10-6-3-7-11-24)18-21-31-19-16-27(33,17-20-31)22-12-14-25(29)15-13-22/h2-15,33H,16-21H2,1H3,(H,30,32)
InChIKey ZMOPTLXEYOVARP-UHFFFAOYSA-N
SMILES CNC(=O)C(CCN1CCC(CC1)(C2=CC=C(C=C2)Cl)O)(C3=CC=CC=C3)C4=CC=CC=C4

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