N-Boc-dolaproine-OH dicyclohexylamine

• CAT Number: I040262
• Molecular Formula: C25H46N2O5
• Molecular Weight: 454.64
• Purity: ≥95%
• Synonyms: N-cyclohexylcyclohexanamine;(2R,3R)-3-hydroxy-2-methyl-3-[(2S)-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidin-2-yl]propanoic acid
• InChI: InChI=1S/C13H23NO5.C12H23N/c1-8(11(16)17)10(15)9-6-5-7-14(9)12(18)19-13(2,3)4;1-3-7-11(8-4-1)13-12-9-5-2-6-10-12/h8-10,15H,5-7H2,1-4H3,(H,16,17);11-13H,1-10H2/t8-,9+,10-;/m1./s1
• InChIKey: ZUYFHKVFPBHZAN-YMQJAAJZSA-N
• SMILES: CC(C(C1CCCN1C(=O)OC(C)(C)C)O)C(=O)O.C1CCC(CC1)NC2CCCCC2

N-Boc-dolaproine-OH dicyclohexylamine(CAT: I040262) is a protected amino acid derivative representing a key residue of the cytotoxic pentapeptide Dolastatin 10 (HY-15580), renowned for its ability to inhibit tubulin polymerization and disrupt mitosis. This compound is supplied as a dicyclohexylamine salt, enhancing its handling and solubility in synthetic applications. As an essential building block in the total synthesis of Dolastatin 10 and its analogs, N-Boc-dolaproine-OH is valuable for antimitotic agent development, SAR studies, and peptide-based anticancer drug discovery. It supports research targeting microtubule dynamics in oncology and contributes to the design of potent cytotoxic peptide therapeutics.