N-Acetyl-L-glutamic acid

• CAT Number: R058851
• CAS Number: 1188-37-0
• Molecular Formula: C7H11NO5
• Molecular Weight: 189.17
• Purity: ≥95%
• Synonyms: (2S)-2-acetamidopentanedioic acid
• InChI: InChI=1S/C7H11NO5/c1-4(9)8-5(7(12)13)2-3-6(10)11/h5H,2-3H2,1H3,(H,8,9)(H,10,11)(H,12,13)/t5-/m0/s1
• InChIKey: RFMMMVDNIPUKGG-YFKPBYRVSA-N
• SMILES: CC(=O)NC(CCC(=O)O)C(=O)O

N-Acetyl-L-glutamic acid (CAT: R058851) is a naturally occurring derivative of L-glutamic acid that plays a critical regulatory role in the urea cycle. It serves as an essential allosteric activator of carbamoyl phosphate synthetase I (CPS1), the first and rate-limiting enzyme in ureagenesis. By stimulating CPS1 activity, NAG promotes ammonia detoxification and nitrogen disposal. In research, N-Acetyl-L-glutamic acid is widely used to study metabolic regulation, amino acid biochemistry, and inborn errors of metabolism such as N-acetylglutamate synthase (NAGS) deficiency. Its biochemical importance also makes it a valuable tool in enzymology, hepatology, and metabolic disease investigations involving nitrogen balance.