Hispidol

• CAT Number: I013210
• CAS Number: 5786-54-9
• Molecular Formula: C₁₅H₁₀O₄
• Molecular Weight: 254.24
• Purity: ≥95%
• Target: TNF-alpha
• Solubility: DMSO: ≥100 mg/mL
• Storage: Store at -20°C
• IUPAC Name: (2Z)-6-hydroxy-2-[(4-hydroxyphenyl)methylidene]-1-benzofuran-3-one
• InChI: InChI=1S/C15H10O4/c16-10-3-1-9(2-4-10)7-14-15(18)12-6-5-11(17)8-13(12)19-14/h1-8,16-17H/b14-7-
• InChIKey: KEZLDSPIRVZOKZ-AUWJEWJLSA-N
• SMILES: C1=CC(=CC=C1C=C2C(=O)C3=C(O2)C=C(C=C3)O)O

Hispidol（Cat No.:I013210）, also known as (Z)-Hispidol, shows promise for research in inflammatory bowel disease (IBD) due to its potential anti-inflammatory properties. It inhibits the adhesion of monocytes to colonic epithelial cells induced by TNF-α, a cytokine involved in the pathogenesis of IBD. Hispidol displays an IC50 value of 0.50 µM, indicating its effectiveness in reducing monocyte adhesion.

Reference

[1]. Kadayat TM, et al. Discovery and structure-activity relationship studies of 2-benzylidene-2,3-dihydro-1H-inden-1-one and benzofuran-3(2H)-one derivatives as a novel class of potential therapeutics for inflammatory bowel disease. Eur J Med Chem. 2017 Sep 8;137:575-597.