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N-(2-Aminoethyl)-5-chloroisoquinoline-8-sulfonamide

N-(2-Aminoethyl)-5-chloroisoquinoline-8-sulfonamide

  • CAT Number: R020489
  • CAS Number: 120615-25-0
  • Molecular Formula: C11H12ClN3O2S
  • Molecular Weight: 285.75
  • Purity: ≥95%
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CKI-7 free base（Cat No.:R020489） is a potent inhibitor of casein kinase 1 (CK1), with an IC50 of 6 μM and a Ki of 8.5 μM. It competitively inhibits CK1 and selectively targets Cdc7 kinase, SGK, S6K1, and MSK1. However, CKI-7 free base exhibits weaker activity against casein kinase II and other protein kinases. This compound has potential applications in research and drug development for studying CK1-related signaling pathways and identifying therapeutic targets associated with CK1-mediated processes.

Catalog Number R020489
CAS Number 120615-25-0
Molecular Formula

C11H12ClN3O2S

Purity 95%
Storage Store at −20°C
IUPAC Name N-(2-aminoethyl)-5-chloroisoquinoline-8-sulfonamide
InChI InChI=1S/C11H12ClN3O2S/c12-10-1-2-11(18(16,17)15-6-4-13)9-7-14-5-3-8(9)10/h1-3,5,7,15H,4,6,13H2
InChIKey OGKYMFFYOWUTKV-UHFFFAOYSA-N
SMILES C1=CC(=C2C=CN=CC2=C1S(=O)(=O)NCCN)Cl

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