CONTACT US
Home > Inhibitors/Agonists>c-Myc> > MYCi361
MYCi361

MYCi361

  • CAT Number: I017779
  • CAS Number: 2289690-31-7
  • Molecular Formula: C₂₆H₁₆ClF₉N₂O₂
  • Molecular Weight: 594.86
  • Purity: ≥95%
Inquiry Now

MYCi361 (Cat No.:I017779) is an MYC inhibitor that binds to intracellular MYC, disrupts MYC/MAX dimers, and impairs MYC-driven gene expression. MYCi361 can bind to MYC with a corresponding Kd value of 3.2 μM. MYCi361 inhibits tumor growth in vivo, increases tumor immune cell infiltration, upregulates PD-L1 on tumors, and sensitizes tumors to anti-PD1 immunotherapy.

Catalog Number I017779
CAS Number 2289690-31-7
Molecular Formula

C₂₆H₁₆ClF₉N₂O₂

Purity 95%
Storage 2-8°C
IUPAC Name 2-[3,5-bis(trifluoromethyl)phenyl]-3-[(4-chlorophenyl)methoxy]-6-[2-methyl-5-(trifluoromethyl)pyrazol-3-yl]phenol
InChI InChI=1S/C26H16ClF9N2O2/c1-38-19(11-21(37-38)26(34,35)36)18-6-7-20(40-12-13-2-4-17(27)5-3-13)22(23(18)39)14-8-15(24(28,29)30)10-16(9-14)25(31,32)33/h2-11,39H,12H2,1H3
InChIKey CKLCWLSEYDDTCN-UHFFFAOYSA-N
SMILES CN1C(=CC(=N1)C(F)(F)F)C2=C(C(=C(C=C2)OCC3=CC=C(C=C3)Cl)C4=CC(=CC(=C4)C(F)(F)F)C(F)(F)F)O
Reference

[1]. Han H, et al. Small-Molecule MYC Inhibitors Suppress Tumor Growth and Enhance Immunotherapy. Cancer Cell. 2019 Nov 11;36(5):483-497.e15.

Request a Quote

Contact Us at MuseChem

We are committed to providing you with reliable, cost-effective solutions for your chemical needs, while ensuring your safety and comfort. Our team of experts is always available to answer your questions and help you navigate the complexities of the chemical industry.

Whether you're looking for a specific product or need help with a custom synthesis project, we're here to help you discover a new world of chemical possibilities. Contact us today to learn more about how we can assist you with all of your chemical needs.

Our goal is to make the process of ordering chemicals as seamless and hassle-free as possible. Let us know how we can assist you, and we'll get back to you as soon as possible. We look forward to hearing from you!