MV1

• CAT Number: I019207
• CAS Number: 1001600-54-9
• Molecular Formula: C₃₃H₄₄N₄O₅
• Molecular Weight: 576.73
• Purity: ≥95%
• Storage: Store at -20°C
• IUPAC Name: methyl (2S)-2-[[(2S)-1-[(2S)-2-cyclohexyl-2-[[(2S)-2-(methylamino)propanoyl]amino]acetyl]pyrrolidine-2-carbonyl]amino]-3,3-diphenylpropanoate
• InChI: InChI=1S/C33H44N4O5/c1-22(34-2)30(38)35-28(25-18-11-6-12-19-25)32(40)37-21-13-20-26(37)31(39)36-29(33(41)42-3)27(23-14-7-4-8-15-23)24-16-9-5-10-17-24/h4-5,7-10,14-17,22,25-29,34H,6,11-13,18-21H2,1-3H3,(H,35,38)(H,36,39)/t22-,26-,28-,29-/m0/s1
• InChIKey: UUPZYAHONNHULX-CJBSCAABSA-N
• SMILES: CC(C(=O)NC(C1CCCCC1)C(=O)N2CCCC2C(=O)NC(C(C3=CC=CC=C3)C4=CC=CC=C4)C(=O)OC)NC

MV1（Cat No.:I019207） acts as an antagonist of the inhibitor of apoptosis (IAP) by binding to the HaloTag ligand. This interaction leads to the knockdown of the HaloTag fusion protein through a protein destabilization mechanism. By targeting IAP, MV1 disrupts its anti-apoptotic function, promoting programmed cell death. The binding of MV1 to the HaloTag ligand allows for selective protein knockdown, providing a valuable tool for studying the functions and interactions of specific proteins in biological systems.

Reference

[1]. Tomoshige S, et al. Efficient protein knockdown of HaloTag-fused proteins using hybrid molecules consisting of IAP antagonist and HaloTag ligand. Bioorg Med Chem. 2016 Jul 15;24(14):3144-8.