For research use only. Not for therapeutic Use.
Multi-target kinase inhibitor 2 (CAT: I040309 is a broad-spectrum kinase inhibitor exhibiting potent activity against EGFR, Her2, VEGFR2, and CDK2, with IC₅₀ values ranging from 40 to 204 nM. It demonstrates notable cytotoxicity in cancer cell lines including HepG2, HeLa, MDA-MB-231, and MCF-7, with IC₅₀ values of 41, 57, 51, and 59 μM, respectively. Mechanistically, compound 5K induces cell cycle arrest and promotes apoptosis, particularly in HepG2 hepatocellular carcinoma cells. Its multi-targeted action and antiproliferative properties make it a valuable tool for oncology research focused on kinase-driven signaling pathways and combination therapy strategies.
| Synonyms | N-[(E)-(3,4-dichlorophenyl)methylideneamino]-4-(7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)benzamide |
| Molecular Formula | C20H14Cl2N6O |
| Purity | ≥95% |
| IUPAC Name | N-[(E)-(3,4-dichlorophenyl)methylideneamino]-4-(7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)benzamide |
| InChI | InChI=1S/C20H14Cl2N6O/c21-16-6-1-12(9-17(16)22)10-26-28-20(29)13-2-4-14(5-3-13)27-19-15-7-8-23-18(15)24-11-25-19/h1-11H,(H,28,29)(H2,23,24,25,27)/b26-10+ |
| InChIKey | YSOXMRLKWYBVKP-NSKAYECMSA-N |
| SMILES | C1=CC(=CC=C1C(=O)NN=CC2=CC(=C(C=C2)Cl)Cl)NC3=NC=NC4=C3C=CN4 |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
