MT 63-78

• CAT Number: I015081
• CAS Number: 1179347-65-9
• Molecular Formula: C₂₁H₁₄N₂O₂
• Molecular Weight: 326.35
• Purity: ≥95%
• Storage: 4°C, protect from light
• IUPAC Name: 5-[4-(2,6-dihydroxyphenyl)phenyl]-1H-indole-3-carbonitrile
• InChI: InChI=1S/C21H14N2O2/c22-11-16-12-23-18-9-8-15(10-17(16)18)13-4-6-14(7-5-13)21-19(24)2-1-3-20(21)25/h1-10,12,23-25H
• InChIKey: IGSYZPLXAFVMKY-UHFFFAOYSA-N
• SMILES: C1=CC(=C(C(=C1)O)C2=CC=C(C=C2)C3=CC4=C(C=C3)NC=C4C#N)O

MT63-78（Cat No.:I015081） is a potent AMP-activated protein kinase (AMPK) activator, with an EC50 of 25 μM. It not only activates AMPK but also induces mitotic arrest and apoptosis. MT63-78 exhibits anti-tumor effects by inhibiting adipogenesis and the mTORC1 pathway, thereby preventing prostate cancer growth. This compound holds promise as a potential therapeutic agent due to its ability to activate AMPK, regulate cell cycle progression, and inhibit tumor-associated pathways.

Reference

[1]. Zadra G, et al. A novel direct activator of AMPK inhibits prostate cancer growth by blocking lipogenesis. EMBO Mol Med. 2014 Apr;6(4):519-38.