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MSAB

MSAB

  • CAT Number: I011959
  • CAS Number: 173436-66-3
  • Molecular Formula: C15H15NO4S
  • Molecular Weight: 305.35
  • Purity: ≥95%
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MSAB is a selective inhibitor of Wnt/β-catenin signaling. MSAB shows potent anti-tumor effects selectively on Wnt-dependent cancer cells in vitro and in mouse cancer models. MSAB binds to β-catenin, promoting its degradation, and specifically downregulates Wnt/β-catenin target genes.

Catalog Number I011959
CAS Number 173436-66-3
Synonyms

MSAB;;Methyl 3-{[(4-methylphenyl)sulfonyl]amino}benzoate

Molecular Formula

C15H15NO4S

Purity 95%
Target Wnt/β-catenin signaling inhibitor
Solubility Soluble in DMSO
Storage Store at 0-8 °C
InChI InChI=1S/C15H15NO4S/c1-11-6-8-14(9-7-11)21(18,19)16-13-5-3-4-12(10-13)15(17)20-2/h3-10,16H,1-2H3
InChIKey CVKBYFCJQSPBOI-UHFFFAOYSA-N
SMILES O=C(OC)C1=CC=CC(NS(=O)(C2=CC=C(C)C=C2)=O)=C1
Reference

</br>1: Hwang SY, Deng X, Byun S, Lee C, Lee SJ, Suh H, Zhang J, Kang Q, Zhang T, Westover KD, Mandinova A, Lee SW. Direct Targeting of β-Catenin by a Small Molecule Stimulates Proteasomal Degradation and Suppresses Oncogenic Wnt/β-Catenin Signaling. Cell Rep. 2016 Jun 28;16(1):28-36. doi: 10.1016/j.celrep.2016.05.071. Epub 2016 Jun 16. PubMed PMID: 27320923; PubMed Central PMCID: PMC4957947.</br></br>

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