MS417

• CAT Number: I008209
• CAS Number: 916489-36-6
• Molecular Formula: C20H19ClN4O2S
• Molecular Weight: 414.908
• Purity: ≥95%
• Solubility: Soluble in DMSO, not in water
• Storage: 0 - 4 °C for short term, or -20 °C for long term
• InChI: InChI=1S/C20H19ClN4O2S/c1-10-11(2)28-20-17(10)18(13-5-7-14(21)8-6-13)22-15(9-16(26)27-4)19-24-23-12(3)25(19)20/h5-8,15H,9H2,1-4H3/t15-/m0/s1
• InChIKey: GGRCIHACOIMRKY-HNNXBMFYSA-N
• SMILES: CC1=C(SC2=C1C(=NC(C3=NN=C(N32)C)CC(=O)OC)C4=CC=C(C=C4)Cl)C

MS417 (Cat.No:I008209), also known as GTPL7512, is a potent and selective BRD4 inhibitor. MS417 inhibits colorectal cancer growth and metastasis. Treatment with inhibitor MS417 potently affects cancer cells, although such effects were not always outright necrosis or apoptosis.

Reference

1:Hu Y, Zhou J, Ye F, Xiong H, Peng L, Zheng Z, Xu F, Cui M, Wei C, Wang X, Wang Z, Zhu H, Lee P, Zhou M, Jiang B, Zhang DY. BRD4 inhibitor inhibits colorectal cancer growth and metastasis. Int J Mol Sci. 2015 Jan 16;16(1):1928-48. doi: 10.3390/ijms16011928. PubMed PMID: 25603177; PubMed Central PMCID: PMC4307342. 2: Liu R, Zhong Y, Li X, Chen H, Jim B, Zhou MM, Chuang PY, He JC. Role of transcription factor acetylation in diabetic kidney disease. Diabetes. 2014 Jul;63(7):2440-53. doi: 10.2337/db13-1810. Epub 2014 Mar 7. PubMed PMID: 24608443; PubMed Central PMCID: PMC4066331.