MRT00033659

• CAT Number: I016664
• CAS Number: 1401731-54-1
• Molecular Formula: C₁₅H₁₄N₄O
• Molecular Weight: 266.3
• Purity: ≥95%
• IUPAC Name: N-[3-(3-methyl-2H-pyrazolo[3,4-b]pyridin-5-yl)phenyl]acetamide
• InChI: InChI=1S/C15H14N4O/c1-9-14-7-12(8-16-15(14)19-18-9)11-4-3-5-13(6-11)17-10(2)20/h3-8H,1-2H3,(H,17,20)(H,16,18,19)
• InChIKey: YFBPGSDPFRCNOY-UHFFFAOYSA-N
• SMILES: CC1=C2C=C(C=NC2=NN1)C3=CC(=CC=C3)NC(=O)C

MRT00033659（Cat No.:I016664） is a potent inhibitor of CK1 (casein kinase 1) and CHK1 (checkpoint kinase 1). It has an IC50 value of 0.9 µM for CK1δ and 0.23 µM for CHK1, making it effective in inhibiting the activity of these kinases. As a pyrazole pyridine analog, MRT00033659 activates the p53 pathway and destabilizes E2F-1. These effects contribute to its potential as an anticancer agent, as modulation of these pathways can impact cell growth, survival, and proliferation.

Reference

[1]. Huart AS, et al. A Casein kinase 1/Checkpoint kinase 1 pyrazolo-pyridine protein kinase inhibitor as novelactivator of the p53 pathway. Bioorg Med Chem Lett. 2013 Oct 15;23(20):5578-85.