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Monastrol

Monastrol

  • CAT Number: R001547
  • CAS Number: 329689-23-8
  • Molecular Formula: C14H16N2O3S
  • Molecular Weight: 292.35
  • Purity: ≥95%
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Monastrol（Cat No.:R001547）, is a synthetic small molecule that acts as a selective inhibitor of the kinesin Eg5. Eg5 is a motor protein involved in cell division, specifically in the formation and function of the mitotic spindle during mitosis. By inhibiting Eg5, Monastrol disrupts the proper assembly and function of the mitotic spindle, leading to mitotic arrest and cell cycle disruption. Due to its specific action on Eg5, Monastrol has been widely used as a valuable tool in cell biology and as a potential candidate for anti-cancer drug development.

Catalog Number R001547
CAS Number 329689-23-8
Molecular Formula

C14H16N2O3S

Purity 95%
Target Kinesin
Solubility Soluble in DMSO
Storage 2-8°C
IUPAC Name ethyl 4-(3-hydroxyphenyl)-6-methyl-2-sulfanylidene-3,4-dihydro-1H-pyrimidine-5-carboxylate
InChI InChI=1S/C14H16N2O3S/c1-3-19-13(18)11-8(2)15-14(20)16-12(11)9-5-4-6-10(17)7-9/h4-7,12,17H,3H2,1-2H3,(H2,15,16,20)
InChIKey LOBCDGHHHHGHFA-UHFFFAOYSA-N
SMILES CCOC(=O)C1=C(NC(=S)NC1C2=CC(=CC=C2)O)C

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