MMV390048

• CAT Number: I008120
• CAS Number: 1314883-11-8
• Molecular Formula: C18H14F3N3O2S
• Molecular Weight: 393.384
• Purity: ≥95%
• Solubility: Soluble in DMSO, not in water
• Storage: Desiccate at RT
• IUPAC Name: 5-(4-methylsulfonylphenyl)-3-[6-(trifluoromethyl)pyridin-3-yl]pyridin-2-amine
• InChI: InChI=1S/C18H14F3N3O2S/c1-27(25,26)14-5-2-11(3-6-14)13-8-15(17(22)24-10-13)12-4-7-16(23-9-12)18(19,20)21/h2-10H,1H3,(H2,22,24)
• InChIKey: RTJQABCNNLMCJF-UHFFFAOYSA-N
• SMILES: CS(=O)(=O)C1=CC=C(C=C1)C2=CC(=C(N=C2)N)C3=CN=C(C=C3)C(F)(F)F

MMV390048, also known as MMV-048, is a novel antimalarial compound belonging to the aminopyridine class. MMV390048 competitively inhibited the binding of only a single protein, P. falciparum PI4 kinase, to the beads. In combination with a partner drug, MMV390048 has the potential to become a new child-friendly treatment for uncomplicated malaria that could be given as one single dose, completing the treatment in just one day instead of the current three days.

Reference

1:Antimalarial efficacy of MMV390048, an inhibitor of Plasmodium phosphatidylinositol 4-kinase. Paquet T, Le Manach C, Cabrera DG, Younis Y, Henrich PP, Abraham TS, Lee MCS, Basak R, Ghidelli-Disse S, Lafuente-Monasterio MJ, Bantscheff M, Ruecker A, Blagborough AM, Zakutansky SE, Zeeman AM, White KL, Shackleford DM, Mannila J, Morizzi J, Scheurer C, Angulo-Barturen I, Martínez MS, Ferrer S, Sanz LM, Gamo FJ, Reader J, Botha M, Dechering KJ, Sauerwein RW, Tungtaeng A, Vanachayangkul P, Lim CS, Burrows J, Witty MJ, Marsh KC, Bodenreider C, Rochford R, Solapure SM, Jiménez-Díaz MB, Wittlin S, Charman SA, Donini C, Campo B, Birkholtz LM, Hanson KK, Drewes G, Kocken CHM, Delves MJ, Leroy D, Fidock DA, Waterson D, Street LJ, Chibale K.Sci Transl Med. 2017 Apr 26;9(387). pii: eaad9735. doi: 10.1126/scitranslmed.aad9735. PMID: 28446690 2:Carbon-14 radiolabeling and tissue distribution evaluation of MMV390048. Sonopo MS, Pillay A, Chibale K, Marjanovic-Painter B, Donini C, Zeevaart JR.J Labelled Comp Radiopharm. 2016 Dec;59(14):680-688. doi: 10.1002/jlcr.3445. Epub 2016 Sep 20. PMID: 27646069