MMP13-IN-2

• CAT Number: I045520
• CAS Number: 935759-55-0
• Molecular Formula: C24H19FN6O4S
• Molecular Weight: 506.51
• Purity: ≥95%
• Synonyms: 5-(3-fluorophenyl)-4-oxo-N-[[3-[2-(1H-1,2,4-triazol-5-yloxy)ethoxy]phenyl]methyl]-3H-thieno[2,3-d]pyrimidine-2-carboxamide
• InChI: InChI=1S/C24H19FN6O4S/c25-16-5-2-4-15(10-16)18-12-36-23-19(18)21(32)29-20(30-23)22(33)26-11-14-3-1-6-17(9-14)34-7-8-35-24-27-13-28-31-24/h1-6,9-10,12-13H,7-8,11H2,(H,26,33)(H,27,28,31)(H,29,30,32)
• InChIKey: MLUCCAMJMIYYED-UHFFFAOYSA-N
• SMILES: C1=CC(=CC(=C1)OCCOC2=NC=NN2)CNC(=O)C3=NC4=C(C(=CS4)C5=CC(=CC=C5)F)C(=O)N3

MMP13-IN-2 (Cat No.: I045520) is a selective small-molecule inhibitor of matrix metalloproteinase-13 (MMP-13), an enzyme involved in extracellular matrix degradation and tissue remodeling. By blocking MMP-13 activity, MMP13-IN-2 helps regulate processes linked to cartilage breakdown, tumor invasion, and metastasis. Researchers use this compound to study osteoarthritis, cancer progression, and fibrotic disorders. Its specificity makes it a valuable tool for dissecting metalloproteinase-dependent pathways and exploring therapeutic strategies aimed at limiting cartilage destruction, inflammation, and abnormal tissue remodeling in musculoskeletal and oncology research.

Reference

[1]. Hiroshi Nara, et al. Discovery of Novel, Highly Potent, and Selective Matrix Metalloproteinase (MMP)-13 Inhibitors with a 1,2,4-Triazol-3-yl Moiety as a Zinc Binding Group Using a Structure-Based Design Approach. J Med Chem. 2017 Jan 26;60(2):608-626.
[Content Brief]