MLS-0437605

• CAT Number: I045500
• CAS Number: 862975-18-6
• Molecular Formula: C16H11FN4O2S
• Molecular Weight: 342.35
• Purity: ≥95%
• Synonyms: N-(4-fluoro-1,3-benzothiazol-2-yl)-5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-amine
• InChI: InChI=1S/C16H11FN4O2S/c1-22-10-7-5-9(6-8-10)14-20-21-15(23-14)19-16-18-13-11(17)3-2-4-12(13)24-16/h2-8H,1H3,(H,18,19,21)
• InChIKey: MJTZAHHYEVPIDG-UHFFFAOYSA-N
• SMILES: COC1=CC=C(C=C1)C2=NN=C(O2)NC3=NC4=C(C=CC=C4S3)F

MLS-0437605 (Cat No.: I045500) is a small-molecule inhibitor identified through high-throughput screening as a modulator of autophagy. It interferes with autophagosome formation or maturation, thereby regulating the degradation of cellular components via the lysosomal pathway. MLS-0437605 is used in cell biology research to study autophagy-related mechanisms in health and disease, including cancer, neurodegeneration, and infection. By selectively altering autophagic flux, it serves as a valuable chemical probe for dissecting autophagy pathways and exploring potential therapeutic strategies targeting dysregulated autophagy in pathological conditions.

Reference

[1]. Lucia Musumeci, et al. Dual-specificity phosphatase 3 deficiency or inhibition limits platelet activation and arterial thrombosis. Circulation. 2015 Feb 17;131(7):656-68.
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