For research use only. Not for therapeutic Use.
ML604440（Cat No.:I018174）is a selective small-molecule inhibitor of the transcription factor STAT3, a critical regulator of cell growth, survival, and immune signaling. By blocking STAT3 activation and downstream gene expression, ML604440 disrupts oncogenic pathways that drive tumor proliferation, angiogenesis, and immune evasion. It has been used in preclinical studies to explore STAT3’s role in cancer, inflammation, and autoimmune disorders. As a pharmacological probe, ML604440 provides researchers with a valuable tool for dissecting STAT3-driven signaling networks and developing therapeutic strategies targeting transcription factor–mediated diseases.
| CAS Number | 1140517-08-3 |
| Synonyms | [(1R)-3-methyl-1-[[2-methyl-2-[[2-(trifluoromethyl)benzoyl]amino]propanoyl]amino]butyl]boronic acid |
| Molecular Formula | C17H24BF3N2O4 |
| Purity | ≥95% |
| IUPAC Name | [(1R)-3-methyl-1-[[2-methyl-2-[[2-(trifluoromethyl)benzoyl]amino]propanoyl]amino]butyl]boronic acid |
| InChI | InChI=1S/C17H24BF3N2O4/c1-10(2)9-13(18(26)27)22-15(25)16(3,4)23-14(24)11-7-5-6-8-12(11)17(19,20)21/h5-8,10,13,26-27H,9H2,1-4H3,(H,22,25)(H,23,24)/t13-/m0/s1 |
| InChIKey | IRZZVDHGNHGNAI-ZDUSSCGKSA-N |
| SMILES | B([C@H](CC(C)C)NC(=O)C(C)(C)NC(=O)C1=CC=CC=C1C(F)(F)F)(O)O |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
