For research use only. Not for therapeutic Use.
ML375（Cat No.:I044354）is a selective, orally bioavailable negative allosteric modulator of the M5 muscarinic acetylcholine receptor (M5 mAChR), a G-protein-coupled receptor primarily expressed in the central nervous system and vasculature. By binding to an allosteric site, ML375 inhibits receptor activity without competing with the endogenous ligand acetylcholine. It has been used in research to explore the role of M5 receptors in dopaminergic signaling, addiction, and cognitive function. ML375 shows promise in preclinical studies for treating neuropsychiatric disorders, including drug addiction and schizophrenia, by modulating neural circuits with minimal off-target effects.
| CAS Number | 1488362-55-5 |
| Synonyms | (9bS)-9b-(4-chlorophenyl)-1-(3,4-difluorobenzoyl)-2,3-dihydroimidazo[2,1-a]isoindol-5-one |
| Molecular Formula | C23H15ClF2N2O2 |
| Purity | ≥95% |
| IUPAC Name | (9bS)-9b-(4-chlorophenyl)-1-(3,4-difluorobenzoyl)-2,3-dihydroimidazo[2,1-a]isoindol-5-one |
| InChI | InChI=1S/C23H15ClF2N2O2/c24-16-8-6-15(7-9-16)23-18-4-2-1-3-17(18)22(30)28(23)12-11-27(23)21(29)14-5-10-19(25)20(26)13-14/h1-10,13H,11-12H2/t23-/m0/s1 |
| InChIKey | GXBAKXRLQAPKEE-QHCPKHFHSA-N |
| SMILES | C1CN([C@]2(N1C(=O)C3=CC=CC=C32)C4=CC=C(C=C4)Cl)C(=O)C5=CC(=C(C=C5)F)F |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
