ML324

• CAT Number: I013855
• CAS Number: 1222800-79-4
• Molecular Formula: C₂₁H₂₃N₃O₂
• Molecular Weight: 349.43
• Purity: ≥95%
• Target: Histone Demethylase
• Solubility: DMSO: ≥ 33 mg/mL
• IUPAC Name: N-[3-(dimethylamino)propyl]-4-(8-hydroxyquinolin-6-yl)benzamide
• InChI: InChI=1S/C21H23N3O2/c1-24(2)12-4-11-23-21(26)16-8-6-15(7-9-16)18-13-17-5-3-10-22-20(17)19(25)14-18/h3,5-10,13-14,25H,4,11-12H2,1-2H3,(H,23,26)
• InChIKey: QDBVSOZTVKXUES-UHFFFAOYSA-N
• SMILES: CN(C)CCCNC(=O)C1=CC=C(C=C1)C2=CC(=C3C(=C2)C=CC=N3)O

ML324 is a potent JMJD2 demethylase inhibitor with demonstrated antiviral activity.
IC50 value: 920 nM(JMJD2E) [1]
Target: JMJD2 demethylase inhibitor
ML324 is a probe molecule that displays submicromolar inhibitory activity toward JMJD2E (in vitro) and possesses excellent in vitro ADME properties. In contrast to previously reported inhibitors of the JMJD proteins, ML324 displays excellent cell permeability providing an opportunity for more extensive cell-based studies of JMJD2 enzymes to be undertaken. In addition, ML324 demonstrates potent anti-viral activity against both herpes simplex virus (HSV) and human cytomegalovirus (hCMV) infection via inhibition viral IE gene expression. ML324 suppresses the formation of HSV plaques, even at high MOI, and blocks HSV-1 reactivation in a mouse ganglia explant model of latently infected mice.

Reference

[1]. Rai G, et al. Discovery of ML324, a JMJD2 demethylase inhibitor with demonstrated antiviral activity.