ML311

• CAT Number: I008096
• CAS Number: 315698-17-0
• Molecular Formula: C23H24F3N3O
• Molecular Weight: 415.46
• Purity: ≥95%
• Synonyms: ML311; ML-311; ML 311; EU-5346; EU 5346; EU5346.;7-[(4-Ethylpiperazin-1-yl)-[4-(trifluoromethyl)phenyl]methyl]quinolin-8-ol
• Solubility: Soluble in DMSO
• Storage: 0 - 4 °C for short term, or -20 °C for long term
• IUPAC Name: 7-[(4-ethylpiperazin-1-yl)-[4-(trifluoromethyl)phenyl]methyl]quinolin-8-ol
• InChI: InChI=1S/C23H24F3N3O/c1-2-28-12-14-29(15-13-28)21(17-5-8-18(9-6-17)23(24,25)26)19-10-7-16-4-3-11-27-20(16)22(19)30/h3-11,21,30H,2,12-15H2,1H3
• InChIKey: NGAPBLRRJSKIRT-UHFFFAOYSA-N
• SMILES: CCN1CCN(CC1)C(C2=CC=C(C=C2)C(F)(F)F)C3=C(C4=C(C=CC=N4)C=C3)O

ML311（Cat No.:I008096）, also referred to as EU-5346, is a highly effective and specific inhibitor of the Protein-Protein Interaction (PPI) between Mcl-1 and Bim. By potently and selectively disrupting this PPI, ML311 offers a valuable tool for investigating lymphoid tumorigenesis and exploring therapeutic approaches to overcome apoptosis resistance pathways activated in drug-resistant tumors. This compound shows promise in developing strategies that bypass resistance mechanisms and enhance the effectiveness of therapies targeting Mcl-1 and Bim interactions.

Reference

1:Bannister T, Koenig M, He Y, Mishra J, Spicer T, Minond D, Saldanha A, Mercer BA, Cameron M, Lena R, Carlson N, Richard D, Cardone M, Hodder P. ML311: A Small Molecule that Potently and Selectively Disrupts the Protein-Protein Interaction of Mcl-1 and Bim: A Probe for Studying Lymphoid Tumorigenesis. 2012 Apr 16 [updated 2013 Mar 14]. Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-. Available from http://www.ncbi.nlm.nih.gov/books/NBK143557/ PubMed PMID: 23762927.