ML167

• CAT Number: I008086
• CAS Number: 1285702-20-6
• Molecular Formula: C19H17N3O3
• Molecular Weight: 335.4
• Purity: ≥95%
• Target: Cyclin-Dependent Kinases
• Solubility: Soluble in DMSO, not in water
• Storage: Store at -20°C
• IC50: 136 nM
• IUPAC Name: [5-[4-[(5-methylfuran-2-yl)methylamino]quinazolin-6-yl]furan-2-yl]methanol
• InChI: InChI=1S/C19H17N3O3/c1-12-2-4-14(24-12)9-20-19-16-8-13(3-6-17(16)21-11-22-19)18-7-5-15(10-23)25-18/h2-8,11,23H,9-10H2,1H3,(H,20,21,22)
• InChIKey: ROCFOIBAEVAOLQ-UHFFFAOYSA-N
• SMILES: CC1=CC=C(O1)CNC2=NC=NC3=C2C=C(C=C3)C4=CC=C(O4)CO

ML167 (Cat No.:I008086) is a potent inhibitor of Cdc2-like kinase 4 (Clk4), demonstrating high selectivity for this kinase. It exhibits an IC50 value of 136 nM against Clk4, making it a promising tool for studying the biological functions of this specific kinase. Notably, ML167 is approximately 10-fold more selective for Clk4 compared to other related kinases, including Clk1, Clk2, Clk3, and Dyrk1A/1B.

Reference

1: Rosenthal AS, Tanega C, Shen M, Mott BT, Bougie JM, Nguyen DT, Misteli T, Auld DS, Maloney DJ, Thomas CJ. An inhibitor of the Cdc2-like kinase 4 (Clk4). 2010 Mar 29 [updated 2011 Mar 3]. Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-. Available from http://www.ncbi.nlm.nih.gov/books/NBK56236/ PubMed PMID: 21735605.