ML RR-S2 CDA

• CAT Number: I002133
• CAS Number: 1638241-89-0
• Molecular Formula: C20H24N10O10P2S2
• Molecular Weight: 690.54
• Purity: ≥95%
• Synonyms: ML RR-S2 CDA; STING-Inducer-1
• Solubility: 10 mM in DMSO
• Storage: Store at -20°C
• InChIKey: IZJJFUQKKZFVLH-LTKSHMRXSA-N
• SMILES: C1C2C(C(C(O2)N3C=NC4=C3N=CN=C4N)OP(=S)(OCC5C(C(C(O5)N6C=NC7=C6N=CN=C7N)O)OP(=O)(O1)S)O)O

ML RR-S2 CDA (CAT: I002133) is a synthetic CDN-derivative molecule that exhibits enhanced stability and lipophilicity compared to endogenous and pathogen-derived CDNs. This compound holds promise for anticancer clinical development as it promotes increased STING (Stimulator of Interferon Genes) signal, which activates the immune response against cancer cells. By improving the activation of the STING pathway, ML RR-S2 CDA may enhance immune recognition and elimination of cancer cells. However, further research is needed to fully understand its pharmacological activity, specific applications, and target information.

Reference

[1]. Dubensky, Thomas W, et al. Compositions and methods for activating /stimulator of interferon gene/-dependent signaling. WO 2014189805 A1
[2]. Corrales L, et al. Direct Activation of STING in the Tumor Microenvironment Leads to Potent and Systemic Tumor Regression and Immunity. Cell Rep. 2015 May 19;11(7):1018-30.