ML-7 hydrochloride - CAS 110448-33-4
ML-7 HCl(Cat No.:I000430) is a potent, reversible, and selective inhibitor of myosin light chain kinase (MLCK). It is cell-permeable and competes with ATP binding to the kinase (Ki = 300 nM). ML-7 HCl effectively inhibits both MLCK and smooth-muscle myosin light chain kinase. Additionally, it exhibits inhibitory activity against protein kinase C (PKC) and cAMP-dependent protein kinase (PKA). The broad inhibition spectrum of ML-7 HCl makes it a valuable tool for studying cellular processes involving these kinases and has potential applications in various fields, including cell biology and pharmacology.
Catalog Number: I000430
CAS Number: 110448-33-4
PubChem Substance ID:355040277
Molecular Formula: C15H17IN2O2S • HCl
Molecular Weight:452.74
Purity: ≥95%
* For research use only. Not for human or veterinary use.
Synonym
Synonyms | 1-((5-iodonaphthalen-1-yl)sulfonyl)-1,4-diazepane hydrochloride |
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Property
Molecular Formula: | C15H17IN2O2S • HCl |
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Molecular Weight | 452.74 |
Target: | ATPase |
Solubility | DMSO: ≥ 43 mg/mL |
Purity | ≥95% |
Storage | Store at -20°C |
IC50 | 300 nM (Ki) |
Computed Descriptor
IUPAC Name | 1-(5-iodonaphthalen-1-yl)sulfonyl-1,4-diazepane;hydrochloride |
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InChI | InChI=1S/C15H17IN2O2S.ClH/c16-14-6-1-5-13-12(14)4-2-7-15(13)21(19,20)18-10-3-8-17-9-11-18;/h1-2,4-7,17H,3,8-11H2;1H |
InChIKey | KDDALCDYHZIZMH-UHFFFAOYSA-N |
SMILES | C1CNCCN(C1)S(=O)(=O)C2=CC=CC3=C2C=CC=C3I.Cl |