ML-7 hydrochloride - CAS 110448-33-4

ML-7 HCl(Cat No.:I000430) is a potent, reversible, and selective inhibitor of myosin light chain kinase (MLCK). It is cell-permeable and competes with ATP binding to the kinase (Ki = 300 nM). ML-7 HCl effectively inhibits both MLCK and smooth-muscle myosin light chain kinase. Additionally, it exhibits inhibitory activity against protein kinase C (PKC) and cAMP-dependent protein kinase (PKA). The broad inhibition spectrum of ML-7 HCl makes it a valuable tool for studying cellular processes involving these kinases and has potential applications in various fields, including cell biology and pharmacology.

Catalog Number: I000430

CAS Number: 110448-33-4

PubChem Substance ID:355040277

Molecular Formula: C15H17IN2O2S • HCl

Molecular Weight:452.74

Purity: ≥95%

* For research use only. Not for human or veterinary use.

Synonym

Synonyms1-((5-iodonaphthalen-1-yl)sulfonyl)-1,4-diazepane hydrochloride

Property

Molecular Formula: C15H17IN2O2S • HCl
Molecular Weight452.74
Target:ATPase
SolubilityDMSO: ≥ 43 mg/mL
Purity≥95%
StorageStore at -20°C
IC50300 nM (Ki)

Computed Descriptor

IUPAC Name1-(5-iodonaphthalen-1-yl)sulfonyl-1,4-diazepane;hydrochloride
InChIInChI=1S/C15H17IN2O2S.ClH/c16-14-6-1-5-13-12(14)4-2-7-15(13)21(19,20)18-10-3-8-17-9-11-18;/h1-2,4-7,17H,3,8-11H2;1H
InChIKeyKDDALCDYHZIZMH-UHFFFAOYSA-N
SMILESC1CNCCN(C1)S(=O)(=O)C2=CC=CC3=C2C=CC=C3I.Cl