GAL-021

• CAT Number: I006928
• CAS Number: 1380341-99-0
• Molecular Formula: C11H22N6O
• Molecular Weight: 254.33
• Purity: ≥95%
• Solubility: Soluble in DMSO
• Storage: Store at -20°C
• IUPAC Name: 2-N-methoxy-2-N-methyl-4-N,6-N-dipropyl-1,3,5-triazine-2,4,6-triamine
• InChI: InChI=1S/C11H22N6O/c1-5-7-12-9-14-10(13-8-6-2)16-11(15-9)17(3)18-4/h5-8H2,1-4H3,(H2,12,13,14,15,16)
• InChIKey: FJNLCHNQVJVCPY-UHFFFAOYSA-N
• SMILES: CCCNC1=NC(=NC(=N1)N(C)OC)NCCC

GAL-021（Cat No.:I006928） is a compound that acts as a blocker of large conductance calcium-activated potassium channels (BKCa-channels). These channels are involved in regulating neuronal excitability and are particularly relevant in the respiratory system. By blocking BKCa-channels, GAL-021 has the potential to modulate respiratory function and address conditions associated with respiratory depression.

Reference

1:Identification and Characterization of GAL-021 as a Novel Breathing Control Modulator. Golder FJ, Dax S, Baby SM, Gruber R, Hoshi T, Ideo C, Kennedy A, Peng S, Puskovic V, Ritchie D, Woodward R, Wardle RL, Van Scott MR, Mannion JC, MacIntyre DE.Anesthesiology. 2015 Nov;123(5):1093-104. doi: 10.1097/ALN.0000000000000844. PMID: 26352381 2:GAL-021 and GAL-160 are Efficacious in Rat Models of Obstructive and Central Sleep Apnea and Inhibit BKCa in Isolated Rat Carotid Body Glomus Cells. Dallas ML, Peers C, Golder FJ, Baby S, Gruber R, MacIntyre DE.Adv Exp Med Biol. 2015;860:361-70. doi: 10.1007/978-3-319-18440-1_41. PMID: 26303501 3:GAL-021, a new intravenous BKCa-channel blocker, is well tolerated and stimulates ventilation in healthy volunteers. McLeod JF, Leempoels JM, Peng SX, Dax SL, Myers LJ, Golder FJ.Br J Anaesth. 2014 Nov;113(5):875-83. doi: 10.1093/bja/aeu182. Epub 2014 Jul 2. PMID: 24989775