ML-324

• CAT Number: I000852
• CAS Number: 1222800-79-4
• Molecular Formula: C₂₁H₂₃N₃O₂
• Molecular Weight: 349.43
• Purity: ≥95%
• Target: Histone Demethylases
• Solubility: DMSO: ≥ 33 mg/mL
• Storage: Store at -20°C
• IC50: 920 nM(JMJD2E) [1]
• IUPAC Name: N-[3-(dimethylamino)propyl]-4-(8-hydroxyquinolin-6-yl)benzamide
• InChI: InChI=1S/C21H23N3O2/c1-24(2)12-4-11-23-21(26)16-8-6-15(7-9-16)18-13-17-5-3-10-22-20(17)19(25)14-18/h3,5-10,13-14,25H,4,11-12H2,1-2H3,(H,23,26)
• InChIKey: QDBVSOZTVKXUES-UHFFFAOYSA-N
• SMILES: OC1=CC(C2=CC=C(C(NCCCN(C)C)=O)C=C2)=CC3=CC=CN=C31

ML-324 (Cat.No:I000852) is a small molecule inhibitor that targets the enzyme mechanistic target of rapamycin (mTOR). It is a potent and selective inhibitor of mTOR complex 1 (mTORC1), a key regulator of cell growth and metabolism. ML-324 has shown promising therapeutic potential in various cancer models by inhibiting mTOR signaling and inducing cell cycle arrest and apoptosis.

Reference

[1]. Rai G, et al. Discovery of ML324, a JMJD2 demethylase inhibitor with demonstrated antiviral activity.