ML-213

• CAT Number: R059569
• CAS Number: 489402-47-3
• Molecular Formula: C17H23NO
• Molecular Weight: 257.4
• Purity: ≥95%
• Target: Potassium Channel
• Solubility: Soluble in DMSO > 10 mM
• Storage: Store at +4C
• InChI: InChI=1S/C17H23NO/c1-10-6-11(2)16(12(3)7-10)18-17(19)15-9-13-4-5-14(15)8-13/h6-7,13-15H,4-5,8-9H2,1-3H3,(H,18,19)
• InChIKey: SIQGKPGBLYKQBB-UHFFFAOYSA-N
• SMILES: CC1=CC(C)=C(NC(C2CC3CCC2C3)=O)C(C)=C1

ML213 is a selective KV7.2 (KCNQ2) and KV7.4 (KCNQ4) channel opener (EC50 values are 230 and 510 nM for KV7.2 and KV7.4 respectively). ML213 displays > 80-fold selectivity against KV7.1, KV7.3 and KV7.5 in a thallium-based fluorescence assay.

Reference

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