ML-099

• CAT Number: R061166
• CAS Number: 496775-95-2
• Molecular Formula: C14H13NO2S
• Molecular Weight: 259.32
• Purity: ≥95%
• Synonyms: 2-(2-phenylethylsulfanyl)pyridine-3-carboxylic acid
• InChI: InChI=1S/C14H13NO2S/c16-14(17)12-7-4-9-15-13(12)18-10-8-11-5-2-1-3-6-11/h1-7,9H,8,10H2,(H,16,17)
• InChIKey: UZERZZRWECLIKE-UHFFFAOYSA-N
• SMILES: C1=CC=C(C=C1)CCSC2=C(C=CC=N2)C(=O)O

ML-099（Cat No.:R061166）is a selective and potent allosteric activator of the atypical kinase WNK1 (With No Lysine [K] 1). It enhances WNK1 kinase activity, influencing downstream signaling pathways, particularly the regulation of ion transport and cell volume via SPAK/OSR1 kinases. ML-099 has been used in studies exploring blood pressure regulation, kidney function, and electrolyte balance. Its specificity makes it a valuable tool for dissecting WNK signaling in physiological and pathophysiological contexts, including hypertension and related disorders. ML-099 aids research into kinase modulation and ion homeostasis.