BAY-41-4109

• CAT Number: I003993
• CAS Number: 298708-81-3
• Molecular Formula: C18H13ClF3N3O2
• Molecular Weight: 395.76
• Purity: ≥95%
• Solubility: Soluble in DMSO, not in water
• Storage: Store at -20°C
• IUPAC Name: methyl (4R)-4-(2-chloro-4-fluorophenyl)-2-(3,5-difluoropyridin-2-yl)-6-methyl-1,4-dihydropyrimidine-5-carboxylate
• InChI: InChI=1S/C18H13ClF3N3O2/c1-8-14(18(26)27-2)15(11-4-3-9(20)5-12(11)19)25-17(24-8)16-13(22)6-10(21)7-23-16/h3-7,15H,1-2H3,(H,24,25)/t15-/m0/s1
• InChIKey: FVNJBPMQWSIGJK-HNNXBMFYSA-N
• SMILES: CC1=C(C(N=C(N1)C2=C(C=C(C=N2)F)F)C3=C(C=C(C=C3)F)Cl)C(=O)OC

BAY 41-4109（Cat No.:I003993） is a highly potent inhibitor specifically targeting the human hepatitis B virus (HBV). It exhibits strong antiviral activity against HBV, with an inhibitory concentration (IC50) of 53 nM. By effectively blocking the replication and spread of the virus, BAY 41-4109 shows promise as a potential therapeutic option for the treatment of HBV infections.

Reference

1:Antiviral activity of Bay 41-4109 on hepatitis B virus in humanized Alb-uPA/SCID mice. Brezillon N, Brunelle MN, Massinet H, Giang E, Lamant C, DaSilva L, Berissi S, Belghiti J, Hannoun L, Puerstinger G, Wimmer E, Neyts J, Hantz O, Soussan P, Morosan S, Kremsdorf D.PLoS One. 2011;6(12):e25096. doi: 10.1371/journal.pone.0025096. Epub 2011 Dec 5. PMID: 22162746 Free PMC Article2:Inhibition of hepatitis B virus replication by Bay 41-4109 and its association with nucleocapsid disassembly. Wu GY, Zheng XJ, Yin CC, Jiang D, Zhu L, Liu Y, Wei L, Wang Y, Chen HS.J Chemother. 2008 Aug;20(4):458-67. PMID: 18676226 3:BAY 41-4109 has multiple effects on Hepatitis B virus capsid assembly. Stray SJ, Zlotnick A.J Mol Recognit. 2006 Nov-Dec;19(6):542-8. PMID: 17006877