MK-8245

• CAT Number: I000183
• CAS Number: 1030612-90-8
• Molecular Formula: C17H16BrFN6O4
• Molecular Weight: 467.25
• Purity: ≥95%
• Target: SCD
• Solubility: DMSO: ≤ 19 mg/mL
• Storage: 3 years -20℃ powder
• IC50: 1 nM (hSCD1) [1]
• IUPAC Name: 2-[5-[3-[4-(2-bromo-5-fluorophenoxy)piperidin-1-yl]-1,2-oxazol-5-yl]tetrazol-2-yl]acetic acid
• InChI: InChI=1S/C17H16BrFN6O4/c18-12-2-1-10(19)7-13(12)28-11-3-5-24(6-4-11)15-8-14(29-22-15)17-20-23-25(21-17)9-16(26)27/h1-2,7-8,11H,3-6,9H2,(H,26,27)
• InChIKey: UJEAABFSXKCSGI-UHFFFAOYSA-N
• SMILES: C1CN(CCC1OC2=C(C=CC(=C2)F)Br)C3=NOC(=C3)C4=NN(N=N4)CC(=O)O

MK-8245 (Cat.No:I000183) is a potent and selective liver-specific thyroid hormone receptor-β (THR-β) agonist. It is being investigated for its potential use in the treatment of dyslipidemia and metabolic disorders. MK-8245 works by activating THR-β in the liver, which leads to improved lipid metabolism and regulation of glucose levels in the body.

Reference

[1]. Oballa RM, et al. Development of a liver-targeted stearoyl-CoA desaturase (SCD) inhibitor (MK-8245) to establish a therapeutic window for the treatment of diabetes and dyslipidemia.J Med Chem. 2011 Jul 28;54(14):5082-96. Epub 2011 Jun 28.