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MK-5172 hydrate

MK-5172 hydrate

  • CAT Number: I001344
  • CAS Number: 1350462-55-3
  • Molecular Formula: C38H52N6O10S
  • Molecular Weight: 784.92
  • Purity: ≥95%
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MK-5172 hydrate (Cat.No:I001344) is a hepatitis C virus (HCV) NS3/4A protease inhibitor. It is used in combination with other antiviral agents to treat chronic HCV infection. MK-5172 works by inhibiting the activity of the NS3/4A protease, which is essential for viral replication. The hydrate form refers to the presence of water molecules in the compound’s crystal structure.

Catalog Number I001344
CAS Number 1350462-55-3
Molecular Formula

C38H52N6O10S

Purity 95%
Target NS3/4a protease
Solubility 10 mM in DMSO
Storage Store at -20°C
IC50 7.4 nM and 7 nM for genotype 1b and 1a respectively, in replicon system [1]
Reference

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<br>[1]. Steven Harper , John A. McCauley , Michael T. Discovery of MK-5172, a Macrocyclic Hepatitis C Virus NS3/4a Protease Inhibitor. ACS Med. Chem. Lett., 2012, 3 (4), pp 332-336
<br>[2]. Summa V, Ludmerer SW, McCauley JA, MK-5172, a selective inhibitor of hepatitis C virus NS3/4a protease with broad activity across genotypes and resistant variants. Antimicrob Agents Chemother. 2012 Aug;56(8):4161-7.
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