Misoprostol

• CAT Number: I004214
• CAS Number: 59122-46-2
• Molecular Formula: C22H38O5
• Molecular Weight: 382.5
• Purity: ≥95%
• Target: Prostaglandin Receptor
• Solubility: 10 mM in DMSO
• Storage: Store at -20C
• InChIKey: OJLOPKGSLYJEMD-URPKTTJQSA-N

Misoprostol(SC29333) is a synthetic prostaglandin E1 (PGE1) analog that is used to prevent gastric ulcers, to treat missed miscarriage, to induce labor, and to induce abortion.Target: Prostaglandin ReceptorMisoprostol is a synthetic analog of natural prostaglandin E1. It produces a dose-related inhibition of gastric acid and pepsin secretion, and enhances mucosal resistance to injury. It is an effective anti-ulcer agent and also has oxytocic properties. Misoprostol seems to inhibit gastric acid secretion by a direct action on the parietal cells through binding to the prostaglandin receptor. Administration of misoprostol to EP3+/+ and EP3-/- mice showed similar levels of infarct rescue, indicating that misoprostol protection was not mediated through the EP3 receptor. Taken together, these findings suggest a novel function for misoprostol as a protective agent in cerebral ischemia acting via the PGE(2) EP2 and/or EP4 receptors [1, 2].

Reference

1:Misoprostol for cervical priming prior to office hysteroscopy works in premenopausal nulliparous but not in postmenopausal women. Bakour S.BJOG. 2017 May 14. doi: 10.1111/1471-0528.14732. [Epub ahead of print] PMID: 28502106 2:Misoprostol for medical treatment of missed abortion: a systematic review and network meta-analysis. Wu HL, Marwah S, Wang P, Wang QM, Chen XW.Sci Rep. 2017 May 10;7(1):1664. doi: 10.1038/s41598-017-01892-0. PMID: 28490770 Free PMC Article3:Assessment of pain during medical abortion with home use of misoprostol. Cavet S, Fiala C, Scemama A, Partouche H.Eur J Contracept Reprod Health Care. 2017 Apr 27:1-5. doi: 10.1080/13625187.2017.1315092. [Epub ahead of print] PMID: 28447484 4:Comparing induction of labour with oral misoprostol or Foley catheter at term: cost effectiveness analysis of a randomised controlled multi-centre non-inferiority trial. Ten Eikelder MLG, van Baaren GJ, Rengerink KO, Jozwiak M, de Leeuw JW, Kleiverda G, Evers I, de Boer K, Brons J, Bloemenkamp KWM, Mol BW.BJOG. 2017 Apr 25. doi: 10.1111/1471-0528.14706. [Epub ahead of print] PMID: 28440898 5:Comparing two regimens of in travaginal misoprostol with intravaginal gemeprost for second-trimesterpregnancy termination: a randomised controlled trial. Koh DSC, Ang EPJ, Coyuco JC, Teo HZ, Huang X, Wei X, Ng MJ, Lim SL, Tan KH.J Fam Plann Reprod Health Care. 2017 Apr 21. pii: jfprhc-2016-101652. doi: 10.1136/jfprhc-2016-101652. [Epub ahead of print] PMID: 28432086 6:Oral Misoprostol Solution for Induction of Labour. Deshmukh VL, Rajamanya AV, Yelikar KA.J Obstet Gynaecol India. 2017 Apr;67(2):98-103. doi: 10.1007/s13224-016-0937-4. Epub 2016 Aug 29. PMID: 28405116 7:Single versus repeat doses of misoprostol for treatment of early pregnancy loss-a randomized clinical trial. Mizrachi Y, Dekalo A, Gluck O, Miremberg H, Dafna L, Feldstein O, Weiner E, Bar J, Sagiv R.Hum Reprod. 2017 Jun 1;32(6):1202-1207. doi: 10.1093/humrep/dex074. PMID: 28402415 8:Protective role of misoprostol in prevention of gentamicin ototoxicity. Dogan M, Polat H, Yasar M, Bayram A, Karatas D, Hira İ, Kale A, Senel F, Özcan İ.Int J Pediatr Otorhinolaryngol. 2017 May;96:140-144. doi: 10.1016/j.ijporl.2017.03.023. Epub 2017 Mar 18. PMID: 28390604 9:Misoprostol Induced Convulsion-A Rare Side Effect of Misoprostol. Sharma N, Das R, Ahanthem SS, Reddy K.J Clin Diagn Res. 2017 Feb;11(2):QD01-QD02. doi: 10.7860/JCDR/2017/23396.9189. Epub 2017 Feb 1. PMID: 28384938 Free PMC Article10:Misoprostol use for second-trimester termination of pregnancy among women with one or more previous cesarean deliveries. Cuellar Torriente M, Steinberg WJ, Joubert G.Int J Gynaecol Obstet. 2017 Apr 4. doi: 10.1002/ijgo.12168. [Epub ahead of print] PMID: 28378361