MIR96-IN-1

• CAT Number: I001196
• CAS Number: 1311982-88-3
• Molecular Formula: C33H48N8O2
• Molecular Weight: 588.79
• Purity: ≥95%
• Target: microRNA-96
• Solubility: 10 mM in DMSO
• Storage: Store at -20°C
• IUPAC Name: N-(3-azidopropyl)-4-[2,6-ditert-butyl-4-[6-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]phenoxy]butanamide
• InChI: InChI=1S/C33H48N8O2/c1-32(2,3)25-20-23(31-37-27-12-11-24(22-28(27)38-31)41-17-15-40(7)16-18-41)21-26(33(4,5)6)30(25)43-19-8-10-29(42)35-13-9-14-36-39-34/h11-12,20-22H,8-10,13-19H2,1-7H3,(H,35,42)(H,37,38)
• InChIKey: LTPQCIXFOJELHJ-UHFFFAOYSA-N
• SMILES: CC(C)(C)C1=CC(=CC(=C1OCCCC(=O)NCCCN=[N+]=[N-])C(C)(C)C)C2=NC3=C(N2)C=C(C=C3)N4CCN(CC4)C

MIR96-IN-1 (Cat No.:I001196) is a small molecule inhibitor that selectively targets the biogenesis of microRNA-96, a known oncomiR involved in promoting cancer cell proliferation and survival. By inhibiting miR-96, MIR96-IN-1 upregulates the expression of its target protein, FOXO1, leading to decreased cell viability and induction of apoptosis in cancer cells.

Reference

[1]. Velagapudi SP, et al. Sequence-based design of bioactive small molecules that target precursor microRNAs. Nat Chem Biol. 2014 Apr;10(4):291-7.
[2]. Haga CL, et al. Small Molecule Inhibition of miR-544 Biogenesis Disrupts Adaptive Responses to Hypoxia by Modulating ATM-mTOR Signaling. ACS Chem Biol. 2015 Oct 16;10(10):2267-76.
[3]. Velagapudi SP, et al. Defining the RNA internal loops preferred by benzimidazole derivatives via 2D combinatorial screening and computational analysis. J Am Chem Soc. 2011 Jul 6;133(26):10111-8.