Minocycline Hydrochloride

  • CAT Number: A000969
  • CAS Number: 13614-98-7
  • Molecular Formula: C₂₃H₂₇N₃O₇.HCl
  • Molecular Weight: 493.94
  • Purity: ≥95%
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Minocycline hydrochloride(cas 13614-98-7) is a tetracycline antibiotic. Displays neuroprotective, antiapoptotic, anti-inflammatory and antimicrobial effects. Acts as a matrix metalloproteinase (MMP) inhibitor; attenuates disease severity in mouse models of multiple sclerosis. Orally active and brain penetrant.

Catalog Number A000969
CAS Number 13614-98-7
Synonyms

NA

Molecular Formula

C₂₃H₂₇N₃O₇.HCl

Purity 95%
Target Antibiotic
Solubility Soluble to 100 mM in DMSO and to 25 mM in water
Storage Store at -20C
InChI InChI=1S/C23H27N3O7.ClH/c1-25(2)12-5-6-13(27)15-10(12)7-9-8-11-17(26(3)4)19(29)16(22(24)32)21(31)23(11,33)20(30)14(9)18(15)28;/h5-6,9,11,17,27-28,31,33H,7-8H2,1-4H3,(H2,24,32);1H/t9-,11-,17-,23-;/m0./s1
InChIKey WTJXVDPDEQKTCV-VQAITOIOSA-N
SMILES CN(C)C1C2CC3CC4=C(C=CC(=C4C(=C3C(=O)C2(C(=C(C1=O)C(=O)N)O)O)O)O)N(C)C.Cl
Reference

1: Danza FM, Falcione M, Bordonaro V, Infante A, Paladini A, Bonomo L.
Minocycline hydrochloride as a soft sclerotizing agent for symptomatic simple
renal and hepatic cysts. Eur Rev Med Pharmacol Sci. 2017 Jan;21(2):408-415.
PubMed PMID: 28165544.</br>
2: Kabuto M, Fujimoto N, Tanaka T. Generalized annular elastolytic giant cell
granuloma successfully treated with the long-term use of minocycline
hydrochloride. Eur J Dermatol. 2017 Apr 1;27(2):178-179. doi:
10.1684/ejd.2016.2926. PubMed PMID: 27873734.</br>
3: Liu ZY, Zhang JD, Zhang L, Yang J, Liu XH. [Analysis of minocycline
hydrochloride combined with Vitapex in treating senile chronic
periodontal-endodontic combined lesions]. Shanghai Kou Qiang Yi Xue. 2016
Aug;25(4):465-468. Chinese. PubMed PMID: 27858072.</br>
4: Accinni A, Bertocchini A, Madafferi S, Natali G, Inserra A. Ultrasound-guided
percutaneous sclerosis of congenital splenic cysts using ethyl alcohol 96% and
minocycline hydrochloride 10%: A pediatric series. J Pediatr Surg. 2016
Sep;51(9):1480-4. doi: 10.1016/j.jpedsurg.2016.05.005. Epub 2016 Jun 7. PubMed
PMID: 27320839.</br>
5: Iijima T, Suwabe T, Sumida K, Hayami N, Mise K, Hoshino J, Takaichi K, Ubara
Y. Prediction of hepatic cyst recurrence after minocycline hydrochloride
aspiration sclerotherapy using cyst computed tomography values. Hepatol Res. 2017
Apr;47(5):419-424. doi: 10.1111/hepr.12763. Epub 2016 Jul 27. PubMed PMID:
27316759.</br>
6: Polonini HC, Silva SL, Cunha CN, Brand&#227;o MA, Ferreira AO. Compatibility of
cholecalciferol, haloperidol, imipramine hydrochloride, levodopa/carbidopa,
lorazepam, minocycline hydrochloride, tacrolimus monohydrate, terbinafine,
tramadol hydrochloride and valsartan in SyrSpend SF PH4 oral suspensions.
Pharmazie. 2016 Apr;71(4):185-91. PubMed PMID: 27209697.

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