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Milnacipran HCl

Milnacipran HCl

  • CAT Number: A001077
  • CAS Number: 101152-94-7
  • Molecular Formula: C15H23ClN2O
  • Molecular Weight: 282.81
  • Purity: ≥95%
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Milnacipran inhibits both norepinephrine transporter (NET) and norepinephrine transporter (SERT) with IC50 of 77 nM and 420 nM, respectively.<br>Milnacipran is mainly excreted in the urine as the parent and glucoronide (> 80%), and only a small fraction (< 10%) is metabolized via N-de-ethylation by the CYP3A4 enzyme.<br>Milnacipran (10 and 30 mg/kg, PO) causes a dose-related increase in the extracellular levels of 5-HT and NA in the medial prefrontal cortex of rats. Milnacipran (30 and 60 mg/kg, PO) significantly reduces the duration of both the immobility time in the forced swimming test and the freezing time in the conditioned fear stress test in rats, which are animal behavioral models for depression and anxiety, respectively.

Catalog Number A001077
CAS Number 101152-94-7
Molecular Formula

C15H23ClN2O

Purity 95%
Target SSRIs
Solubility Soluble in DMSO > 10 mM
Storage 3 years -20C powder

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