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Milademetan

Milademetan

  • CAT Number: I012065
  • CAS Number: 1398568-47-2
  • Molecular Formula: C30H34Cl2FN5O4
  • Molecular Weight: 618.531
  • Purity: ≥95%
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Milademetan (CAT: I012065) is a potent and selective inhibitor of MDM2, a protein that negatively regulates the tumor suppressor protein p53. By inhibiting the interaction between MDM2 and p53, milademetan promotes p53 activation and stabilization, leading to cell cycle arrest, apoptosis, and inhibition of tumor growth. Milademetan has demonstrated efficacy in preclinical models and is being investigated as a potential treatment for various p53 wild-type solid tumors and hematological malignancies. Clinical trials are underway to evaluate the safety and efficacy of milademetan as a targeted therapy for cancer.

Catalog Number I012065
CAS Number 1398568-47-2
Molecular Formula

C30H34Cl2FN5O4

Purity 95%
Storage Room temperature
InChI InChI=1S/C30H34Cl2FN5O4/c1-28(2)8-10-29(11-9-28)30(18-5-3-15(31)13-19(18)37-27(30)41)21(17-7-12-35-24(32)22(17)33)23(38-29)26(40)36-16-4-6-20(25(34)39)42-14-16/h3,5,7,12-13,16,20-21,23,38H,4,6,8-11,14H2,1-2H3,(H2,34,39)(H,36,40)(H,37,41)/t16-,20+,21+,23-,30-/m1/s1
InChIKey RYAYYVTWKAOAJF-QISPRATLSA-N
SMILES CC1(CCC2(CC1)C3(C(C(N2)C(=O)NC4CCC(OC4)C(=O)N)C5=C(C(=NC=C5)Cl)F)C6=C(C=C(C=C6)Cl)NC3=O)C

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