For research use only. Not for therapeutic Use.
Migoprotafib (Cat No.:I044023) is a selective, ATP-competitive inhibitor of fibroblast growth factor receptors (FGFR1, FGFR2, and FGFR3), with a strong preference for FGFR2 fusions and mutations. It is being investigated for its potential in treating tumors with FGFR dysregulation, including intrahepatic cholangiocarcinoma and urothelial cancers. By blocking aberrant FGFR signaling, Migoprotafib can inhibit tumor cell proliferation and survival. Its precision makes it a promising candidate in targeted cancer therapy, especially for patients harboring FGFR-driven malignancies. Supplied for preclinical research and drug development purposes.
| CAS Number | 2377352-49-1 |
| Synonyms | (3R)-1′-[3-(3,4-dihydro-2H-1,5-naphthyridin-1-yl)-1H-pyrazolo[3,4-b]pyrazin-6-yl]spiro[3H-1-benzofuran-2,4′-piperidine]-3-amine |
| Molecular Formula | C25H26N8O |
| Purity | ≥95% |
| IUPAC Name | (3R)-1'-[3-(3,4-dihydro-2H-1,5-naphthyridin-1-yl)-1H-pyrazolo[3,4-b]pyrazin-6-yl]spiro[3H-1-benzofuran-2,4'-piperidine]-3-amine |
| InChI | InChI=1S/C25H26N8O/c26-22-16-5-1-2-8-19(16)34-25(22)9-13-32(14-10-25)20-15-28-21-23(29-20)30-31-24(21)33-12-4-6-17-18(33)7-3-11-27-17/h1-3,5,7-8,11,15,22H,4,6,9-10,12-14,26H2,(H,29,30,31)/t22-/m1/s1 |
| InChIKey | RGCGBFIARQENML-JOCHJYFZSA-N |
| SMILES | C1CC2=C(C=CC=N2)N(C1)C3=NNC4=NC(=CN=C43)N5CCC6(CC5)[C@@H](C7=CC=CC=C7O6)N |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
