BC1618

• CAT Number: I023049
• CAS Number: 2222094-18-8
• Molecular Formula: C24H24F3NO2
• Molecular Weight: 415.45
• Purity: 98%
• Synonyms: BC1618; BC-1618; BC 1618
• Solubility: To be determined
• Storage: Store at -20°C
• IUPAC Name: 1-(dibenzylamino)-3-(4-(trifluoromethyl)phenoxy)propan-2-ol
• InChI: InChI=1S/C24H24F3NO2/c25-24(26,27)21-11-13-23(14-12-21)30-18-22(29)17-28(15-19-7-3-1-4-8-19)16-20-9-5-2-6-10-20/h1-14,22,29H,15-18H2
• InChIKey: LGTYABNNHILKHF-UHFFFAOYSA-N
• SMILES: OC(COC1=CC=C(C(F)(F)F)C=C1)CN(CC2=CC=CC=C2)CC3=CC=CC=C3

BC1618（Cat No.:I023049） is a potent inhibitor of Fbxo48, a protein involved in the degradation of activated pAMPKα. By preventing the degradation of pAMPKα, BC1618 enhances the biological activity of Ampk and improves insulin resistance. Additionally, BC1618 promotes mitochondrial fission, facilitates autophagy, and enhances hepatic insulin sensitivity in obese mice fed a high-fat diet.

Reference

1: Liu Y, Jurczak MJ, Lear TB, Lin B, Larsen MB, Kennerdell JR, Chen Y, Huckestein BR, Nguyen MK, Tuncer F, Jiang Y, Monga SP, O’Donnell CP, Finkel T, Chen BB, Mallampalli RK. A Fbxo48 inhibitor prevents pAMPKα degradation and ameliorates insulin resistance. Nat Chem Biol. 2021 Mar;17(3):298-306. doi: 10.1038/s41589-020-00723-0. Epub 2021 Jan 25. PMID: 33495648.
2: Marquet RL, de Bruin RW, Dallinga RJ, Singh SK, Jeekel J. Modulation of tumor growth by allogeneic blood transfusion. J Cancer Res Clin Oncol. 1986;111(1):50-3. doi: 10.1007/BF00402776. PMID: 3949850.