For research use only. Not for therapeutic Use.
Micrococcin P1（Cat No.:R007199）is a potent antimicrobial peptide isolated from Micrococcus luteus. It exhibits broad-spectrum antibacterial activity, particularly against Gram-positive bacteria. Micrococcin P1 functions by inhibiting protein synthesis, binding to bacterial ribosomes, and preventing the elongation of polypeptides. This mechanism of action makes it a promising candidate for the development of novel antibiotics, especially in combating antibiotic-resistant bacteria. Its stability and selective toxicity toward bacteria, rather than mammalian cells, further enhance its potential for therapeutic applications. Ongoing research explores its application in various pharmaceutical formulations.
| CAS Number | 67401-56-3 |
| Synonyms | 2’-[(11S,14Z,21S,28S)-14-ethylidene-9,10,11,12,13,14,20,21,27,28-decahydro-28-[(1R)-1-hydroxyethyl]-11-[(1R)-1-hydroxyethyl]-21-(1-methylethyl)-9,12,19,26-tetraoxo-19H,26H-8,5:18,15:25,22:32,29-tetranitrilo-5H,15H-pyrido[3,2-m][1,11,17,24,4,7,20,27]t |
| Molecular Formula | C48H49N13O9S6 |
| Purity | ≥95% |
| Target | Bacterial |
| Storage | -20°C |
| IUPAC Name | 2-[2-[(26E)-26-ethylidene-12,29-bis(1-hydroxyethyl)-14,21,28,31-tetraoxo-19-propan-2-yl-10,17,24,34-tetrathia-6,13,20,27,30,35,36,37,38-nonazahexacyclo[30.2.1.18,11.115,18.122,25.02,7]octatriaconta-1(35),2(7),3,5,8,11(38),15,18(37),22,25(36),32-undecaen-5-yl]-1,3-thiazol-4-yl]-N-[(E)-1-(2-hydroxypropylamino)-1-oxobut-2-en-2-yl]-1,3-thiazole-4-carboxamide |
| InChI | InChI=1S/C48H49N13O9S6/c1-8-24(37(65)49-12-20(5)62)51-38(66)28-15-73-46(56-28)32-18-74-45(58-32)26-11-10-23-36(50-26)27-13-75-48(53-27)35(22(7)64)61-41(69)31-17-76-47(57-31)33(19(3)4)59-39(67)30-16-72-44(55-30)25(9-2)52-42(70)34(21(6)63)60-40(68)29-14-71-43(23)54-29/h8-11,13-22,33-35,62-64H,12H2,1-7H3,(H,49,65)(H,51,66)(H,52,70)(H,59,67)(H,60,68)(H,61,69)/b24-8+,25-9+ |
| InChIKey | MQGFYNRGFWXAKA-IQEGOQEASA-N |
| SMILES | C/C=C/1\C2=NC(=CS2)C(=O)NC(C3=NC(=CS3)C(=O)NC(C4=NC(=CS4)C5=C(C=CC(=N5)C6=NC(=CS6)C7=NC(=CS7)C(=O)N/C(=C/C)/C(=O)NCC(C)O)C8=NC(=CS8)C(=O)NC(C(=O)N1)C(C)O)C(C)O)C(C)C |
| Reference | Antibiotic-producing organisms in faeces and sewage. Su T.L. Brit. J. Exp. Path. 1948, 29, 466.<br/><br/>The preparation and some properties of purified micrococcin. Heatley N.G. and Doery H.M. Biochem. J. 1951, 50, 247.<br/><br/> Micrococcin P1: Structure, biology and synthesis. Ciufolini M.A. and Lefranc D. Nat. Prod. Reports 2010, 27, 330. <br/><br/>Isolation of three new antibiotics, thiocillins I, II and III, related to micrococcin. P. Shoji J. J. Antibiot. 1976, 29, 366.</span></p> |
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