MHY1485

• CAT Number: I003156
• CAS Number: 326914-06-1
• Molecular Formula: C17H21N7O4
• Molecular Weight: 387.4
• Purity: ≥95%
• Target: mTOR
• Solubility: DMSO: ＞ 9.5 mg/mL
• Storage: 2-8°C
• IUPAC Name: 4,6-dimorpholin-4-yl-N-(4-nitrophenyl)-1,3,5-triazin-2-amine
• InChI: InChI=1S/C17H21N7O4/c25-24(26)14-3-1-13(2-4-14)18-15-19-16(22-5-9-27-10-6-22)21-17(20-15)23-7-11-28-12-8-23/h1-4H,5-12H2,(H,18,19,20,21)
• InChIKey: MSSXBKQZZINCRI-UHFFFAOYSA-N
• SMILES: C1COCCN1C2=NC(=NC(=N2)NC3=CC=C(C=C3)[N+](=O)[O-])N4CCOCC4

MHY1485（Cat No.:I003156） is an mTOR activator that modulates cellular processes. By inhibiting the fusion between autophagosomes (vesicles involved in autophagy) and lysosomes, it disrupts the autophagic process. This disruption results in the accumulation of LC3II protein and the formation of enlarged autophagosomes. This compound’s ability to modulate autophagy provides insights into the regulation of this essential cellular pathway and highlights its potential in studying autophagy-related diseases and developing therapeutic interventions targeting autophagy dysregulation.

Reference

1:MHY1485 ameliorates UV-induced skin cell damages via activating mTOR-Nrf2 signaling. Yang B, Xu QY, Guo CY, Huang JW, Wang SM, Li YM, Tu Y, He L, Bi ZG, Ji C, Cheng B.Oncotarget. 2017 Feb 21;8(8):12775-12783. doi: 10.18632/oncotarget.14299. PMID: 28061443 Free PMC Article2:MHY1485 activates mTOR and protects osteoblasts from dexamethasone. Zhao S, Chen C, Wang S, Ji F, Xie Y.Biochem Biophys Res Commun. 2016 Dec 9;481(3-4):212-218. doi: 10.1016/j.bbrc.2016.10.104. PMID: 27884298 3:Inhibitory effect of mTOR activator MHY1485 on autophagy: suppression of lysosomal fusion. Choi YJ, Park YJ, Park JY, Jeong HO, Kim DH, Ha YM, Kim JM, Song YM, Heo HS, Yu BP, Chun P, Moon HR, Chung HY.PLoS One. 2012;7(8):e43418. doi: 10.1371/journal.pone.0043418. Epub 2012 Aug 22. Erratum in: PLoS One. 2013;8(1). doi:10.1371/annotation/e3163ad5-f3d8-4a21-b3e1-f2033a76f9db. PMID: 22927967 Free PMC Article