MG 149

• CAT Number: I000968
• CAS Number: 1243583-85-8
• Molecular Formula: C22H28O3
• Molecular Weight: 340.5
• Purity: ≥95%
• Target: Histone Acetyltransferases
• Solubility: in DMSO > 10 mM
• Storage: Store at -20°C
• IC50: 74/47 uM (Tip60/MOF)
• IUPAC Name: 2-[2-(4-heptylphenyl)ethyl]-6-hydroxybenzoic acid
• InChI: InChI=1S/C22H28O3/c1-2-3-4-5-6-8-17-11-13-18(14-12-17)15-16-19-9-7-10-20(23)21(19)22(24)25/h7,9-14,23H,2-6,8,15-16H2,1H3,(H,24,25)
• InChIKey: WBHQYBZRTAEHRR-UHFFFAOYSA-N
• SMILES: OC1=C(C(O)=O)C(CCC2=CC=C(CCCCCCC)C=C2)=CC=C1

MG149（Cat No.:I000968） is a small molecule inhibitor of histone acetyltransferases (HATs), specifically targeting the Tip60 and MOF enzymes. It has demonstrated potent inhibitory activity against Tip60 and MOF with IC50 values of 74 μM and 47 μM, respectively. MG149 has been shown to inhibit acetylation of histone H4 and reduce Tip60-mediated transcriptional activation. MG149 has the potential as a tool compound for studying the functions of HATs in cellular processes such as DNA damage response and gene regulation.

Reference

1:Mol Microbiol. 2011 Jul;81(2):327-39. doi: 10.1111/j.1365-2958.2011.07717.x. Epub 2011 Jun 22. Transcriptional regulation of MG_149, an osmoinducible lipoprotein gene from Mycoplasma genitalium.Zhang W,Baseman JB, PMID: 21692875 PMCID: PMC3196619 DOI: 10.1111/j.1365-2958.2011.07717.x Abstract: Transcriptional regulation remains poorly understood in Mycoplasma genitalium, the smallest self-replicating cell and the causative agent of a spectrum of urogenital diseases. Previously, we reported that MG_149, a lipoprotein-encoding gene, was highly induced under physiological hyperosmolarity conditions. In this study we further analysed MG_149 transcription with a focus on the identification of promoter elements and regulatory mechanisms. We established MG_149 as a genuine osmoinducible gene that exhibited the highest transcript abundance compared with other lipoprotein genes. Using genetic approaches, we demonstrated that the -10 region of the MG_149 promoter was essential for osmoinduction. Moreover, we showed that MG_149 osmoinduction was regulated by DNA supercoiling, as the presence of novobiocin decreased MG_149 expression in a dose-dependent manner. Taken together, these results indicate that DNA supercoiling participates in controlling MG_149 expression during in vivo-like conditions.© 2011 Blackwell Publishing Ltd.