MG-132

• CAT Number: I001273
• CAS Number: 133407-82-6
• Molecular Formula: C₂₆H₄₁N₃O₅
• Molecular Weight: 475.6
• Purity: ≥95%
• Target: Proteasome
• Solubility: 10 mM in DMSO
• Storage: 3 years -20C powder
• IC50: 100 nM( proteasome); 1.2 uM(calpain) [1]
• InChI: InChI=1S/C26H41N3O5/c1-17(2)12-21(15-30)27-24(31)22(13-18(3)4)28-25(32)23(14-19(5)6)29-26(33)34-16-20-10-8-7-9-11-20/h7-11,15,17-19,21-23H,12-14,16H2,1-6H3,(H,27,31)(H,28,32)(H,29,33)/t21-,22-,23-/m0/s1
• InChIKey: TZYWCYJVHRLUCT-VABKMULXSA-N
• SMILES: CC(C)CC(C=O)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)OCC1=CC=CC=C1

MG-132(CAT: I001273) is a potent and selective proteasome inhibitor. It inhibits the chymotrypsin-like activity of the 20S proteasome, leading to the accumulation of ubiquitinated proteins and the inhibition of protein degradation. MG-132 is commonly used in research studies to investigate the role of the proteasome in protein turnover and cellular processes. It has been shown to induce cell cycle arrest, and apoptosis, and inhibit the growth of cancer cells. MG-132 is a valuable tool in studying the proteasome pathway and its potential as a therapeutic target for various diseases, including cancer.

Reference

1:[Synergistic anti-tumor effect of obatoclax and MG-132 in esophageal cancer cell line CaES-17]. Zhao XY, Lin QH, Que FC, Gu CP, Yu L, Liu SW.Nan Fang Yi Ke Da Xue Xue Bao. 2016 Apr;36(4):506-13. Chinese. PMID: 27113178 2:Proteasome inhibitor MG-132 enhances histone deacetylase inhibitor SAHA-induced cell death of chronic myeloid leukemia cells by an ROS-mediated mechanism and downregulation of the Bcr-Abl fusion protein. Zhou W, Zhu W, Ma L, Xiao F, Qian W.Oncol Lett. 2015 Nov;10(5):2899-2904. Epub 2015 Sep 2. PMID: 26722260 Free PMC Article3:Inhibition of autophagy promotes cell apoptosis induced by the proteasome inhibitor MG-132 in human esophageal squamous cell carcinoma EC9706 cells. Liu D, Gao M, Yang Y, Qi YU, Wu K, Zhao S.Oncol Lett. 2015 May;9(5):2278-2282. Epub 2015 Mar 17. PMID: 26137056 Free PMC Article4:Chemically assisted somatic cell nuclear transfer without micromanipulator in the goat: effects of demecolcine, cytochalasin-B, and MG-132 on the efficiency of a manual method of oocyte enucleation using a pulled Pasteur pipette. Hosseini SM, Hajian M, Forouzanfar M, Ostadhosseini S, Moulavi F, Ghanaei HR, Gourbai H, Shahverdi AH, Vosough AD, Nasr-Esfahani MH.Anim Reprod Sci. 2015 Jul;158:11-8. doi: 10.1016/j.anireprosci.2015.04.002. Epub 2015 Apr 15. PMID: 25956201 5:Upregulated ROS production induced by the proteasome inhibitor MG-132 on XBP1 gene expression and cell apoptosis in Tca-8113 cells. Chen HY, Ren XY, Wang WH, Zhang YX, Chen SF, Zhang B, Wang LX.Biomed Pharmacother. 2014 Jul;68(6):709-13. doi: 10.1016/j.biopha.2014.07.011. Epub 2014 Jul 18. PMID: 25092240 6:MCPIP1 contributes to the toxicity of proteasome inhibitor MG-132 in HeLa cells by the inhibition of NF-κB. Skalniak L, Dziendziel M, Jura J.Mol Cell Biochem. 2014 Oct;395(1-2):253-63. doi: 10.1007/s11010-014-2134-z. Epub 2014 Jul 4. PMID: 24992982 Free PMC Article7:Nigrostriatal pathway degeneration in rats after intraperitoneal administration of proteasome inhibitor MG-132. Wójcik S, Spodnik JH, Spodnik E, Dziewiątkowski J, Moryś J.Folia Neuropathol. 2014;52(1):41-55. PMID: 24729342 Free Article8:The role of Src protein in the process formation of PC12 cells induced by the proteasome inhibitor MG-132. Tarjányi O, Berta G, Harci A, Bacsa EB, Stark B, Pap M, Szeberényi J, Sétáló G Jr.Neurochem Int. 2013 Nov;63(5):413-22. doi: 10.1016/j.neuint.2013.07.008. Epub 2013 Jul 31. PMID: 23911694 9:Proteasome inhibitor MG-132 induces MCPIP1 expression. Skalniak L, Koj A, Jura J.FEBS J. 2013 Jun;280(11):2665-74. doi: 10.1111/febs.12264. Epub 2013 May 7. PMID: 23551903 Free PMC Article10:Therapeutic effect of MG-132 on diabetic cardiomyopathy is associated with its suppression of proteasomal activities: roles of Nrf2 and NF-κB. Wang Y, Sun W, Du B, Miao X, Bai Y, Xin Y, Tan Y, Cui W, Liu B, Cui T, Epstein PN, Fu Y, Cai L.Am J Physiol Heart Circ Physiol. 2013 Feb 15;304(4):H567-78. doi: 10.1152/ajpheart.00650.2012. Epub 2012 Dec 7. PMID: 23220333 Free Article