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Metrifonate

Metrifonate

  • CAT Number: I003928
  • CAS Number: 52-68-6
  • Molecular Formula: C4H8Cl3O4P
  • Molecular Weight: 257.44
  • Purity: ≥95%
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Metrifonate(CAT: I003928), also known as trichlorfon, is an organophosphorus compound that has been used as an insecticide and as an anthelmintic agent. However, it is primarily recognized for its use in the treatment of schistosomiasis, a parasitic disease caused by Schistosoma worms. Metrifonate functions as a reversible acetylcholinesterase inhibitor, leading to the accumulation of acetylcholine at cholinergic synapses and subsequent paralysis of the worms. Due to its ability to selectively target schistosomes, metrifonate has been employed in various regions where schistosomiasis is endemic.

Catalog Number I003928
CAS Number 52-68-6
Molecular Formula

C4H8Cl3O4P

Purity 95%
Solubility H2O: ≥ 30 mg/mL
Storage Store at -20°C
IUPAC Name 2,2,2-trichloro-1-dimethoxyphosphorylethanol
InChI InChI=1S/C4H8Cl3O4P/c1-10-12(9,11-2)3(8)4(5,6)7/h3,8H,1-2H3
InChIKey NFACJZMKEDPNKN-UHFFFAOYSA-N
SMILES COP(=O)(C(C(Cl)(Cl)Cl)O)OC
Reference

<p style=”/line-height:25px/”>
<span style=”font-size:12px;”><span style=”font-family:arial,helvetica,sans-serif;”><span style=”font-variant-ligatures: normal; orphans: 2; widows: 2;”>1.Holmstedt, Bo, et al. &quot;Metrifonate.&quot;&nbsp;</span><i style=”font-family: Arial, sans-serif; font-size: 13px; font-variant-ligatures: normal; orphans: 2; widows: 2;”>Archives of toxicology</i><span style=”font-variant-ligatures: normal; orphans: 2; widows: 2;”>&nbsp;41.1 (1978): 3-29.<br />
2.</span><span style=”font-variant-ligatures: normal; orphans: 2; widows: 2;”>Morris, John C., et al. &quot;Metrifonate benefits cognitive, behavioral, and global function in patients with Alzheimer&#39;s disease.&quot;&nbsp;</span><i style=”font-family: Arial, sans-serif; font-size: 13px; font-variant-ligatures: normal; orphans: 2; widows: 2;”>Neurology</i><span style=”font-variant-ligatures: normal; orphans: 2; widows: 2;”>&nbsp;50.5 (1998): 1222-1230.<br />
3.</span><span style=”font-variant-ligatures: normal; orphans: 2; widows: 2;”>Cummings, Jeffrey L., et al. &quot;Metrifonate treatment of the cognitive deficits of Alzheimer&#39;s disease.&quot;&nbsp;</span><i style=”font-family: Arial, sans-serif; font-size: 13px; font-variant-ligatures: normal; orphans: 2; widows: 2;”>Neurology</i><span style=”font-variant-ligatures: normal; orphans: 2; widows: 2;”>&nbsp;50.5 (1998): 1214-1221.</span></span></span></p>

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