Methyldopa

• CAT Number: A000638
• CAS Number: 555-30-6
• Molecular Formula: C10H13NO4
• Molecular Weight: 211.20
• Purity: ≥95%
• Synonyms: 555-30-6; Alphamethyldopa; Aldomet; Alpha medopa; Dopamet
• Target: Neuronal Signaling
• Solubility: Soluble to 75 mM in DMSO
• Storage: -20°C
• IUPAC Name: (2S)-2-amino-3-(3,4-dihydroxyphenyl)-2-methylpropanoic acid
• InChI: InChI=1S/C10H13NO4/c1-10(11,9(14)15)5-6-2-3-7(12)8(13)4-6/h2-4,12-13H,5,11H2,1H3,(H,14,15)/t10-/m0/s1
• InChIKey: CJCSPKMFHVPWAR-JTQLQIEISA-N
• SMILES: C[C@](CC1=CC(=C(C=C1)O)O)(C(=O)O)N

Methyldopa（Cat No.:A000638）is a centrally acting antihypertensive agent with the molecular formula C10H13NO4, primarily used to treat high blood pressure, especially during pregnancy. It functions as a prodrug, metabolized into α-methylnorepinephrine, which stimulates central α2-adrenergic receptors. This reduces sympathetic outflow, leading to decreased heart rate, vascular resistance, and blood pressure. Methyldopa is typically administered orally and is known for its safety profile in managing gestational hypertension. Common side effects include drowsiness, dry mouth, and dizziness. It remains a valuable therapeutic option when other antihypertensives are contraindicated or less effective.