Cytarabine

  • CAT Number: A000876
  • CAS Number: 147-94-4
  • Molecular Formula: C9H13N3O5
  • Molecular Weight: 243.2
  • Purity: ≥95%
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Cytarabine is an antimetabolic agent and DNA synthesis inhibitor with IC50 of 16 nM in wild-type CCRF-CEM cells.<br>Cytarabine (AraC) is phosphorylated into a triphosphate form (Ara-CTP) involving deoxycytidine kinase (dCK), which competes with dCTP for incorporation into DNA, and then blocks DNA synthesis by inhibiting the function of DNA and RNA polymerases. Cytarabine displays a higher growth inhibitory activity towards wild-type CCRF-CEM cells compared to other acute myelogenous leukemia (AML) cells with IC50 of 16 nM.<br>Cytarabine is highly effective against acute leukaemias, which causes the characteristic G1/S blockage and synchronization, and increases the survival time for leukaemic Brown Norway rats in a weak dose-related fashion indicating that the use of higher dosages of Cytarabine does not contribute to its antileukaemic effectiveness in man.

Catalog Number A000876
CAS Number 147-94-4
Molecular Formula

C9H13N3O5

Purity 95%
Target DNA Synthesis
Solubility Limited solubility
Storage 3 years -20C powder
InChIKey UHDGCWIWMRVCDJ-CCXZUQQUSA-N

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