Methoxamine Hydrochloride (Mixture of Diastereomers)

  • CAT Number: R045405
  • CAS Number: 61-16-5
  • Molecular Formula: C₁₁H₁₈ClNO₃
  • Molecular Weight: 247.72
  • Purity: ≥95%
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Methoxamine Hydrochloride is an alpha-1 adrenergic agonist that causes prolonged peripheral vasoconstriction.

Catalog Number R045405
CAS Number 61-16-5
Molecular Formula

C₁₁H₁₈ClNO₃

Purity 95%
Storage -20°C
Reference

</br>1: Bell D, Duffin A, Gruss HJ, Pediconi C, Jacobs A. A randomised, controlled,</br> crossover study to investigate the pharmacodynamics, pharmacokinetics and safety </br> of 1R,2S-methoxamine hydrochloride (NRL001) in healthy elderly subjects.</br> Colorectal Dis. 2014 Mar;16 Suppl 1:27-35. doi: 10.1111/codi.12543. PubMed PMID: </br> 24499494.</br>2: Simpson JA, Bush D, Gruss HJ, Jacobs A, Pediconi C, Scholefield JH. A</br> randomised, controlled, crossover study to investigate the safety and response of</br> 1R,2S-methoxamine hydrochloride (NRL001) on anal function in healthy volunteers. </br> Colorectal Dis. 2014 Mar;16 Suppl 1:5-15. doi: 10.1111/codi.12541. PubMed PMID:</br> 24499492.</br>3: BRILL IC, KRUEGER JD, McCAWLEY EL. Restoration of sinus rhythm in experimental</br> and clinical ventricular arrhythmias by methoxamine hydrochloride. Am J Cardiol. </br> 1959 Mar;3(3):307-13. PubMed PMID: 13626865.</br>4: COCKREM F. Effect of a sympathomimetic agent (methoxamine hydrochloride) on</br> growth of hair in the house mouse (Mus musculus). Nature. 1959 Feb</br> 28;183(4661):614-5. English, French. PubMed PMID: 13632814.</br>5: DURHAM JR. Severe reaction to methoxamine hydrochloride; report of a case</br> occurring during treatment of paroxysmal supraventricular tachycardia. J Am Med</br> Assoc. 1958 Aug 9;167(15):1835-7. PubMed PMID: 13563189.</br>6: LAHTI RE, BRILL IC, MCCAWLEY EL. The effect of methoxamine hydrochloride</br> (vasoxyl) on cardiac rhythm. J Pharmacol Exp Ther. 1955 Nov;115(3):268-74. PubMed</br> PMID: 13272176.</br>7: NEW AND nonofficial remedies: methoxamine hydrochloride. J Am Med Assoc. 1954 </br> May 8;155(2):124-5. PubMed PMID: 13151899.</br>8: CHOTKOWSKI LA, POWELL CP, RACKLIFFE RL. Methoxamine hydrochloride in the</br> treatment of paroxysmal supraventricular tachycardia; report of three cases. N</br> Engl J Med. 1954 Apr 22;250(16):674-6. PubMed PMID: 13154605.</br>9: Lee JC, Fripp RR, Downing SE. Myocardial responses to alpha-adrenoceptor</br> stimulation with methoxamine hydrochloride in lambs. Am J Physiol. 1982</br> Mar;242(3):H405-10. PubMed PMID: 6278955.</br>10: ZIMDAHL WT. Use of methoxamine hydrochloride in treatment of paroxysmal</br> supraventricular tachycardia. N Y State J Med. 1963 Jul 15;63:2101-4. PubMed</br> PMID: 14003671.</br>11: SHECTOR WE, McLAUGHLIN JT, DOWLING C. Ventricular arrythmia induced by</br> methoxamine hydrochloride. J Am Med Assoc. 1955 Jul 23;158(12):1025-6. PubMed</br> PMID: 14392049.</br>12: POE MF. Use of methoxamine hydrochloride as a pressor agent during spinal</br> analgesia. Anesthesiology. 1952 Jan;13(1):89-93. PubMed PMID: 14894846.</br></br>

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