Metaxalone

• CAT Number: I002176
• CAS Number: 1665-48-1
• Molecular Formula: C12H15NO3
• Molecular Weight: 221.3
• Purity: ≥95%
• Target: Others
• Solubility: 10 mM in DMSO
• Storage: -20°C
• InChIKey: IMWZZHHPURKASS-UHFFFAOYSA-N

Metaxalone (Cat.No:I002176) is a muscle relaxant used to alleviate discomfort associated with musculoskeletal conditions such as muscle spasms and pain. It acts on the central nervous system to produce a sedative effect, helping to relieve muscle tension and promote relaxation. Metaxalone is typically prescribed as part of a comprehensive treatment plan that includes rest, physical therapy, and other measures to improve muscle function. 

Reference

1:Postmortem Metaxalone (Skelaxin®) Data from North Carolina. Bishop-Freeman SC, Miller A, Hensel EM, Winecker RE.J Anal Toxicol. 2015 Oct;39(8):629-36. doi: 10.1093/jat/bkv066. PMID: 26378137 2:Serotonin syndrome associated with therapeutic metaxalone in a patient with cirrhosis. Surmaitis RM, Nappe TM, Cook MD.Am J Emerg Med. 2016 Feb;34(2):346.e5-6. doi: 10.1016/j.ajem.2015.06.043. Epub 2015 Jun 19. No abstract available. PMID: 26159819 3:A rare fatality attributed solely to metaxalone. Curtis B, Jenkins C, Wiens AL.J Anal Toxicol. 2015 May;39(4):321-3. doi: 10.1093/jat/bkv008. Epub 2015 Feb 10. PMID: 25673649 4:Serotonin syndrome following metaxalone overdose and therapeutic use of a selective serotonin reuptake inhibitor. Martini DI, Nacca N, Haswell D, Cobb T, Hodgman M.Clin Toxicol (Phila). 2015 Mar;53(3):185-7. doi: 10.3109/15563650.2015.1009993. Epub 2015 Feb 11. PMID: 25671244 5:Serotonin syndrome associated with metaxalone overdose. Bosak AR, Skolnik AB.J Med Toxicol. 2014 Dec;10(4):402-5. doi: 10.1007/s13181-014-0404-5. PMID: 24805103 Free PMC Article6:Development and validation of a stability-indicating assay including the isolation and characterization of degradation products of metaxalone by LC-MS. Rao RN, Farah H, Sahu PK, Janarthan M, Naidu ChG.Biomed Chromatogr. 2013 Dec;27(12):1733-40. doi: 10.1002/bmc.2987. Epub 2013 Jul 23. PMID: 23881540 7:Development of a Stability-Indicating RP-UPLC Method for Rapid Determination of Metaxalone and its Degradation Products in Solid Oral Dosage Form. Trivedi RK, Patel MC.Sci Pharm. 2012 Apr-Jun;80(2):353-66. doi: 10.3797/scipharm.1112-08. Epub 2012 Feb 21. PMID: 22896822 Free PMC Article8:Metaxalone estimation in biological matrix using high-throughput LC-MS/MS bioanalytical method. Goswami D, Saha A, Gurule S, Khuroo A, Monif T, Vats P.J Chromatogr B Analyt Technol Biomed Life Sci. 2012 Aug 1;902:132-6. doi: 10.1016/j.jchromb.2012.05.034. Epub 2012 Jun 4. PMID: 22766230 9:New Stability-Indicating RP-HPLC Method for Determination of Diclofenac Potassium and Metaxalone from their Combined Dosage Form. Panda SS, Patanaik D, Ravi Kumar BV.Sci Pharm. 2012 Jan-Mar;80(1):127-37. doi: 10.3797/scipharm.1109-16. Epub 2011 Dec 5. PMID: 22396909 Free PMC Article10:Pediatric metaxalone ingestions reported to Texas poison control centers, 2000-2007. Forrester MB.Pediatr Emerg Care. 2010 Jan;26(1):15-8. doi: 10.1097/PEC.0b013e3181c330dc. PMID: 20042913