Mesna

• CAT Number: A001214
• CAS Number: 19767-45-4
• Molecular Formula: C2H5O3S2 • Na
• Molecular Weight: 164.2
• Purity: ≥95%
• Storage: 3 years -20C powder
• InChIKey: XOGTZOOQQBDUSI-UHFFFAOYSA-M

Mesna is a sulfhydryl compound that is used to reduce the incidence of hemorrhagic cystitis associated with certain chemotherapeutic agents. Mesna is converted to a free thiol compound in the kidney, where it binds to and inactivates acrolein and other urotoxic metabolites of ifosfamide and cyclophosphamide, thereby reducing their toxic effects on the urinary tract during urinary excretion. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus). Mesnex is indicated as a prophylactic agent in reducing the incidence of ifosfamide-induced hemorrhagic cystitis.

Reference

1:Protective potential of different compounds and their combinations with MESNA against sulfur mustard-induced cytotoxicity and genotoxicity. Jost P, Fikrova P, Svobodova H, Pejchal J, Stetina R.Toxicol Lett. 2017 May 8;275:92-100. doi: 10.1016/j.toxlet.2017.05.010. [Epub ahead of print] PMID: 28495614 2:Sepsis like acute hypersensitivity syndrome related to mesna. Ercan N, Aysegul E, Burcak B, Ilknur B.J Eur Acad Dermatol Venereol. 2017 Mar 8. doi: 10.1111/jdv.14198. [Epub ahead of print] No abstract available. PMID: 28271573 3:Effect of Submucosal Mesna Application on Mucoperichondrial Elevation in Septoplasty. Eren SB, Yenigun A, Tugrul S, Goktas SS, Dogan R, Calim OF, Ozturan O.J Craniofac Surg. 2017 Jan;28(1):e94-e96. doi: 10.1097/SCS.0000000000003307. PMID: 27997451 4:Single dose intratympanic mesna application inhibits propylene glycol induced cholesteatoma formation. Ismi O, Karabulut YY, Bal KK, Vayisoglu Y, Unal M.J Laryngol Otol. 2017 Mar;131(3):215-220. doi: 10.1017/S002221511600983X. Epub 2016 Dec 20. PMID: 27995828 5:Pazopanib induced a partial response in a patient with metastatic fibrosarcomatous dermatofibrosarcoma protuberans without genetic translocations resistant to mesna, doxorubicin, ifosfamide and dacarbazine chemotherapy and gemcitabine-docetaxel chemotherapy. Miyagawa T, Kadono T, Kimura T, Saigusa R, Yoshizaki A, Miyagaki T, Yamada D, Masui Y, Fujita H, Sato S.J Dermatol. 2017 Mar;44(3):e21-e22. doi: 10.1111/1346-8138.13717. Epub 2016 Dec 18. No abstract available. PMID: 27988943 6:Ipilimumab-Induced Polyneuropathy; Ibuprofen-Induced Allergic-Type Liver Injury; Trimethoprim-Sulfamethoxazole-Induced Immune Thrombocytopenia in Children; Mesna-Induced Fixed Drug Eruption; Digoxin-Induced Ocular Toxicity. Mancano MA.Hosp Pharm. 2016 Sep;51(8):623-627. PMID: 27698499 7:Looking beyond the angiotensin receptor blocker: A case of anaphylaxis to mesna. Robertson LM, Clark A.Ann Allergy Asthma Immunol. 2016 Sep;117(3):324-5. doi: 10.1016/j.anai.2016.06.023. Epub 2016 Jul 14. No abstract available. PMID: 27424127 8:Treatment with Mesna and n-3 polyunsaturated fatty acids ameliorates experimental ulcerative colitis in rats. Triantafyllidis I, Poutahidis T, Taitzoglou I, Kesisoglou I, Lazaridis C, Botsios D.Int J Exp Pathol. 2015 Dec;96(6):433-43. doi: 10.1111/iep.12163. Epub 2016 Jan 19. PMID: 26852691 Free PMC Article9:Fixed Drug Eruption Due to Mesna. Soria A, Lebrun-Vignes B, Le Forestier N, Francès C.J Investig Allergol Clin Immunol. 2015;25(6):444-5. No abstract available. PMID: 26817144 Free Article10:New investigations into the stability of Mesna using LC-MS/MS and NMR. Salman D, Swinden J, Peron JM, Barton S, Nabhani-Gebara S.Expert Rev Anticancer Ther. 2016;16(1):123-30. doi: 10.1586/14737140.2016.1121106. PMID: 26568378