Mesaconitine

• CAT Number: I002944
• CAS Number: 2752-64-9
• Molecular Formula: C33H45NO11
• Molecular Weight: 631.71
• Purity: ≥95%
• Solubility: 10 mM in DMSO
• Storage: 2-8°C(protect from light)
• IUPAC Name: [(1S,2R,3R,4R,5R,6S,7S,8R,9R,13R,14R,16S,17S,18R)-8-acetyloxy-5,7,14-trihydroxy-6,16,18-trimethoxy-13-(methoxymethyl)-11-methyl-11-azahexacyclo[7.7.2.12,5.01,10.03,8.013,17]nonadecan-4-yl] benzoate
• InChI: InChI=1S/C33H45NO11/c1-16(35)45-33-21-18(13-31(39,28(43-6)26(33)37)27(21)44-29(38)17-10-8-7-9-11-17)32-20(41-4)12-19(36)30(15-40-3)14-34(2)25(32)22(33)23(42-5)24(30)32/h7-11,18-28,36-37,39H,12-15H2,1-6H3/t18-,19-,20+,21-,22+,23+,24-,25?,26+,27-,28+,30+,31-,32+,33-/m1/s1
• InChIKey: XUHJBXVYNBQQBD-TUWOXVOMSA-N
• SMILES: CC(=O)OC12C3C(CC(C3OC(=O)C4=CC=CC=C4)(C(C1O)OC)O)C56C(CC(C7(C5C(C2C6N(C7)C)OC)COC)O)OC

Mesaconitine（Cat No.:I002944） is an aconite alkaloid found in Aconiti tuber. It exhibits the ability to elevate intracellular calcium levels ([Ca2+]i) in endothelial cells. This effect is achieved through the influx of calcium ions from the extracellular space. Mesaconitine’s action on endothelial cells increases intracellular calcium concentration, potentially impacting various cellular processes and signaling pathways regulated by calcium.

Reference

[1]. Ogura J, et al. Mesaconitine-induced relaxation in rat aorta: role of Na+/Ca2+ exchangers in endothelial cells. Eur J Pharmacol. 2004 Jan 12;483(2-3):139-46.

[2]. Mitamura M, et al. Mesaconitine-induced relaxation in rat aorta: involvement of Ca2+ influx and nitric-oxide synthase in the endothelium. Eur J Pharmacol. 2002 Feb 2;436(3):217-25.

[3]. Murayama M, et al. Mechanism of analgesic action of mesaconitine. I. Relationship between analgesic effect and central monoamines or opiate receptors. Eur J Pharmacol. 1984 May 18;101(1-2):29-36.